Researchers at the Virginia Tech Carilion Research Institute have reported the first experimental evidence that supports the theory that a soccer ball-shaped nanoparticle commonly called a buckyball is the result of a breakdown of larger structures rather than being built atom-by-atom from the ground up.
Technically known as fullerenes, these spherical carbon molecules have shown great promise for uses in medicine, solar energy, and optoelectronics. But finding applications for these peculiar structures has been difficult because no one knows exactly how they are formed.
Two theories compete regarding the molecular mechanisms that make fullerenes. The first and oldest is the "bottom-up" theory, which says these carbon cages are built atom-by-atom, like the construction of a Lego model. The second, more recent, theory takes a "top-down" approach, suggesting that fullerenes form when much larger structures break into constituent parts.
After several years of debate with little more than computational models in support of how the top-down theory might work, researchers led by Harry Dorn, a professor at the research institute, have discovered the missing link: asymmetrical fullerenes that are formed from larger structures appear to settle into stable fullerenes.
The discovery appeared online Sept. 15 in the journal Nature Chemistry.
"Understanding the molecular mechanics of how fullerenes and their many variations are formed is not just a curiosity," said Dorn, who has been researching metallofullerenes – fullerenes with a few atoms of metal held within – for more than two decades. "It would give us insights into new, better ways to prepare them. Fullerenes and metallofullerenes are already involved in hundreds of biomedical studies. The ability to create large numbers of a wide variety of metallofullerenes would be a giant building block that would take the field to new heights."
The medicinal promise of metallofullerenes stems from the atoms of metal caged within them. Because the metal atoms are trapped in a cage of carbon, they do not react with the outside world, making their side-effect risks low in both number and intensity.
For example, one particular metallofullerene with gadolinium at its core has been shown to be up to 40 times better as a contrast agent in magnetic resonance imaging scans for diagnostic imaging than options now commercially available. Current experiments are also directed at using metallofullerenes to carry therapeutic radioactive ions to target cancer tissue.
"A better understanding of the formation of fullerenes and metallofullerenes may allow the development of new contrast agents for magnetic resonance imaging at commercial-level quantities," said Jianyuan Zhang, a graduate student in Dorn's laboratory and the first author of the paper. "These larger quantities will facilitate a next generation of contrast agents with multiple targets."
Dorn's new study hinges on the isolation and purification of approximately 100 micrograms — roughly the size of several specks of pepper — of a particular metallofullerene consisting of 84 carbon atoms with two additional carbon atoms and two yttrium atoms trapped inside.
When Dorn and his colleagues determined the metallofullerene's exact structure using nuclear magnetic resonance imaging and single crystal X-ray analysis, they made a startling discovery —the asymmetrical molecule could theoretically collapse to form nearly every known fullerene and metallofullerene.
All the process would require would be a few minor perturbations — the breaking of only a few molecular bonds — and the cage would become highly symmetrical and stable.
This insight, Dorn said, supports the theory that fullerenes are formed from graphene — a single sheet of carbon just one atom thick — when key molecular bonds begin to break down. And although the study focuses on fullerenes with yttrium trapped inside, it also shows that the carbon distribution looks similar for empty cages, suggesting regular fullerenes form the same way.
"Not only are the findings presented in Dr. Dorn's paper extremely interesting, but the study represents a real milestone in the field," said Takeshi Akasaka, a professor of chemistry at the University of Tsukuba in Japan and an authority in the field of metallofullerene research, who was not involved in the study. "The study presents physical evidence for a process of metallofullerene creation that most scientists in the field initially scoffed at."
Dorn said scientists have questioned the bottom-up theory of fullerene formation ever since it was discovered that fullerenes were formed from asteroids colliding with Earth and fullerenes were found in interstellar space.
"With this study, we hope to be that much closer to understanding their formation and creating entirely new classes of fullerenes and metallofullerenes that could be useful in medicine as well as in other fields that haven't even occurred to us yet," Dorn said.
"Dr. Dorn's insight into the fundamental process whereby fullerenes are formed is a major contribution to the field," said Michael Friedlander, executive director of the Virginia Tech Carilion Research Institute. "Understanding the molecular steps in their formation is key to realizing fully the potential of this versatile and potentially potent family of chemicals in medicine. Dr. Dorn's contributions to understanding these molecules are paving the way for the formulation of targeted novel diagnostics, therapeutics, and the combination of both—theranostics. This approach will provide an important component for tomorrow's arsenal of precision medicine."
Dorn and Zhang's research collaborators include Faye Bowles, a graduate student researcher; Marilyn Olmstead, a professor of chemistry; and Alan Balch, a distinguished professor of chemistry; all from the University of California, Davis.
Also participating were Daniel Bearden, a research scientist with the Hollings Marine Laboratory at the National Institute of Standards and Technology, and Tim Fuhrer, now an assistant professor of chemistry at Radford University.
Researchers from Virginia Tech who worked on the study include Richard Helm, an associate professor of biochemistry; W. Keith Ray, a senior research associate in biochemistry; Youqing Ye, a graduate student in chemistry; Caitlyn Dixon, an undergraduate student in chemistry; and Kim Harich, an analytical chemist senior in biochemistry.
Paula Byron | EurekAlert!
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
Chlamydia: How bacteria take over control
28.03.2017 | Julius-Maximilians-Universität Würzburg
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Physics and Astronomy
28.03.2017 | Health and Medicine
28.03.2017 | Life Sciences