Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New DNA-based technique for assembly of nano- and micro-sized particles

14.09.2007
Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have developed a new method for controlling the self-assembly of nanometer and micrometer-sized particles.

The method, based on designed DNA shells that coat a particle’s surface, can be used to manipulate the structure – and therefore the properties and potential uses – of numerous materials that may be of interest to industry. For example, such fine-tuning of materials at the molecular level promises applications in efficient energy conversion, cell-targeted systems for drug delivery, and bio-molecular sensing for environmental monitoring and medical applications.

The novel method, for which a patent application has been filed, was developed by Brookhaven researchers Mathew M. Maye, Dmytro Nykypanchuk, Daniel van der Lelie, and Oleg Gang and is described in the September 12 online edition of Small, a leading journal on nanoscience and nanotechnology.

“Our method is unique because we attached two types of DNA with different functions to particles’ surfaces,” said Gang, who leads the research team. “The first type – complementary single strands of DNA – forms a double helix. The second type is non-complementary, neutral DNA, which provides a repulsive force. In contrast to previous studies in which only complementary DNA strands are attached to the particles, the addition of the repulsive force allows for regulating the size of particle clusters and the speed of their self-assembly with more precision.”

... more about:
»Assembly »Complementary »DNA »technique »type

“When two non-complementary DNA strands are brought together in a fixed volume that is typically occupied by one DNA strand, they compete for space,” said Maye. “Thus, the DNA acts as a molecular spring, and this results in the repulsive force among particles, which we can regulate. This force allows us to more easily manipulate particles into different formations.”

The researchers performed the experiments on gold nanoparticles – measuring billionths of a meter – and polystyrene (a type of plastic) microparticles – measuring millionths of a meter. These particles served as models for the possibility of using the technique with other small particles. The scientists synthesized DNA to chemically react with the particles. They controlled the assembly process by keeping the total amount of DNA constant, while varying the relative fraction of complementary and non-complementary DNA. This technique allowed for regulating assembly over a very broad range, from forming clusters consisting of millions of particles to almost keeping individual particles separate in a non-aggregating form.

“It is like adjusting molecular springs,” said Nykypanchuk. “If there are too many springs, particles will ‘bounce’ from each other, and if there are too few springs, particles will likely stick to each other.”

The method was tested separately on the nano- and micro-sized particles, and was equally successful in providing greater control than using only complementary DNA in assembling both types of particles into large or small groupings.

To determine the structure of the assembled particles and to learn how to modify them for particular uses, the researchers used transmission electron microscopy to visualize the clusters, as well as x-ray scattering at the National Synchrotron Light Source to study particles in solution, the DNA’s natural environment.

Diane Greenberg | EurekAlert!
Further information:
http://www.bnl.gov/newsroom

Further reports about: Assembly Complementary DNA technique type

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>