About 2 million people die of malaria every year, of which more than a million are children in sub-Saharan Africa. Malaria is caused by a protozoan parasite belonging to the genus Plasmodium, and Plasmodium falciparum is responsible for the most severe form of malaria.
Due to the increasing incidence of resistance to existing drugs, there is a growing need to discover new and more effective drugs against malaria. In a new study publishing in PLoS Computational Biology on September 14, 2007, Dr. Tatu and colleagues from the Indian Institute of Science have constructed a chaperone interaction network for the parasite which provides, for the first time, a rational basis for the anti-malarial effect of known drugs and highlights new proteins that can potentially be used in the fight against malaria.
Recent reports from several labs point to a critical role played by a group of proteins termed molecular chaperones. These chaperones participate in the maintenance and growth of cells and are implicated in parasite survival and growth. Although a vast body of information is available regarding individual chaperones, few studies have attempted a systems level analysis of chaperone function. The researchers’ systems-level approach provides information on 95 different chaperones in the parasite and also provides insights into their business partners and cellular processes that they might regulate.
Analysis of the network reveals the broad range of functions regulated by chaperones. The network predicts involvement of chaperones in chromatin remodeling, protein trafficking, and cytoadherence. Importantly, it allows making predictions regarding the functions of hypothetical proteins based on their interactions. Analysis of the network provides a rational basis for the anti-malarial activity of geldanamycin, a well-known Hsp90 inhibitor, and provides a theoretical basis for further experiments designed toward understanding the involvement of this important class of molecules in parasite biology.
Andrew Hyde | alfa
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology