Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epigenetics Could Lead to Better Cancer Diagnosis

26.02.2007
DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA’s four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off.

DNA methylation patterns differ dramatically between healthy and diseased tissue and thereby can serve as biomarkers, opening a window into earlier detection of disease. In a special issue of the journal Disease Markers published in February 2007, ten articles explore the details and challenges of cancer epigenetics.

Writing in the editorial, Guest Editor Martin Widschwendter (Institute for Women’s Health, University College London) emphasizes that, “The concept of early detection of tumours before they spread and become incurable, represents one of the most important challenges in reducing the impact of the growing burden of cancer worldwide…Altered patterns of DNA methylation can be detected with high sensitivity, potentially providing us with diagnostic, prognostic and predictive information, and can be reversed by appropriate drug treatment. These possibilities make cancer epigenetics a most exciting field of current translational research.”

Four articles document different epigenetic alterations in lung, prostate, ovarian and colorectal cancer. The observation of abnormal methylation in the RASSF1A gene in a broad spectrum of tumors is reviewed by Luke B. Hesson, Wendy N.Cooper and Farida Latif. Heidi Fiegl and Karim Elmasry review how DNA-methylation can form the basis for diagnostics and therapeutic monitors.

... more about:
»DNA »DNA methylation »epigenetic »methylation

Epigenetic silencing of the MGMT gene encoding a DNA repair enzyme was recently found to be of predictive value in a randomised clinical trial for newly diagnosed glioblastoma, reviewed by Peter Hau, Roger Stupp and Monika E. Hegi. The possibility of using epigenetic changes in normal tissue to predict an individuals risk of developing cancer is reviewed by Hengmi Cui.

Biostatisticians Todd A. Alonzo and Kimberly D. Siegmund provide an excellent review about various statistical approaches to analysis of the wealth of information gained by DNA methylation studies.

Finally, Craig A. Cooney discusses the recent emergence of “epigenetic epidemiology” where the causes of DNA methylations might be understood and used to direct epigenetics toward improved health and longevity.

Epigenetic Markers
Special issue of Disease Markers, Volume 23, Issues 1-2
Guest Editor: Martin Widschwendter
Table of Contents
EDITORIAL
5-methylcytosine – the fifth base of DNA: The fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?

Martin Widschwendter

The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma

Keith M. Kerr, Janice S. Galler, Jeffrey A. Hagen, Peter W. Laird, and Ite A. Laird-Offringa

Epigenetic markers for molecular detection of prostate cancer
Vera L. Costa, Rui Henrique & Carmen Jerónimo
Epigenetic Markers and Response to Chemotherapy in Cancer
Gordon Strathdee
DNA Methylation in Colorectal Cancer – impact on screening and therapy monitoring modalities ?

Marion Zitt, Matthias Zitt and Hannes M. Müller

The role of Rassf1a methylation in cancer
Luke B. Hesson, Wendy N.Cooper and Farida Latif
Cancer diagnosis, risk assessment and prediction of therapeutic response by means of DNA methylation markers

Heidi Fiegl and Karim Elmasry

MGMT methylation status : the advent of stratified therapy in glioblastoma?
Peter Hau, Roger Stupp, and Monika E. Hegi
Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer
Hengmi Cui
Statistical methods for evaluating DNA methylation as a marker for early detection or prognosis

Todd A. Alonzo and Kimberly D. Siegmund

Epigenetics – DNA-Based Mirror of Our Environment?
Craig A. Cooney

Astrid Engelen | alfa
Further information:
http://www.iospress.nl

Further reports about: DNA DNA methylation epigenetic methylation

More articles from Life Sciences:

nachricht Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg

nachricht Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>