Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epigenetics Could Lead to Better Cancer Diagnosis

26.02.2007
DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA’s four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off.

DNA methylation patterns differ dramatically between healthy and diseased tissue and thereby can serve as biomarkers, opening a window into earlier detection of disease. In a special issue of the journal Disease Markers published in February 2007, ten articles explore the details and challenges of cancer epigenetics.

Writing in the editorial, Guest Editor Martin Widschwendter (Institute for Women’s Health, University College London) emphasizes that, “The concept of early detection of tumours before they spread and become incurable, represents one of the most important challenges in reducing the impact of the growing burden of cancer worldwide…Altered patterns of DNA methylation can be detected with high sensitivity, potentially providing us with diagnostic, prognostic and predictive information, and can be reversed by appropriate drug treatment. These possibilities make cancer epigenetics a most exciting field of current translational research.”

Four articles document different epigenetic alterations in lung, prostate, ovarian and colorectal cancer. The observation of abnormal methylation in the RASSF1A gene in a broad spectrum of tumors is reviewed by Luke B. Hesson, Wendy N.Cooper and Farida Latif. Heidi Fiegl and Karim Elmasry review how DNA-methylation can form the basis for diagnostics and therapeutic monitors.

... more about:
»DNA »DNA methylation »epigenetic »methylation

Epigenetic silencing of the MGMT gene encoding a DNA repair enzyme was recently found to be of predictive value in a randomised clinical trial for newly diagnosed glioblastoma, reviewed by Peter Hau, Roger Stupp and Monika E. Hegi. The possibility of using epigenetic changes in normal tissue to predict an individuals risk of developing cancer is reviewed by Hengmi Cui.

Biostatisticians Todd A. Alonzo and Kimberly D. Siegmund provide an excellent review about various statistical approaches to analysis of the wealth of information gained by DNA methylation studies.

Finally, Craig A. Cooney discusses the recent emergence of “epigenetic epidemiology” where the causes of DNA methylations might be understood and used to direct epigenetics toward improved health and longevity.

Epigenetic Markers
Special issue of Disease Markers, Volume 23, Issues 1-2
Guest Editor: Martin Widschwendter
Table of Contents
EDITORIAL
5-methylcytosine – the fifth base of DNA: The fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?

Martin Widschwendter

The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma

Keith M. Kerr, Janice S. Galler, Jeffrey A. Hagen, Peter W. Laird, and Ite A. Laird-Offringa

Epigenetic markers for molecular detection of prostate cancer
Vera L. Costa, Rui Henrique & Carmen Jerónimo
Epigenetic Markers and Response to Chemotherapy in Cancer
Gordon Strathdee
DNA Methylation in Colorectal Cancer – impact on screening and therapy monitoring modalities ?

Marion Zitt, Matthias Zitt and Hannes M. Müller

The role of Rassf1a methylation in cancer
Luke B. Hesson, Wendy N.Cooper and Farida Latif
Cancer diagnosis, risk assessment and prediction of therapeutic response by means of DNA methylation markers

Heidi Fiegl and Karim Elmasry

MGMT methylation status : the advent of stratified therapy in glioblastoma?
Peter Hau, Roger Stupp, and Monika E. Hegi
Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer
Hengmi Cui
Statistical methods for evaluating DNA methylation as a marker for early detection or prognosis

Todd A. Alonzo and Kimberly D. Siegmund

Epigenetics – DNA-Based Mirror of Our Environment?
Craig A. Cooney

Astrid Engelen | alfa
Further information:
http://www.iospress.nl

Further reports about: DNA DNA methylation epigenetic methylation

More articles from Life Sciences:

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>