Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a type of programmed cell death called apoptosis. A new study published in the February issue of Cancer Cell identifies compounds and mechanisms that can overcome a specific type of resistance to chemotherapeutic-induced apoptosis. The findings may have application for treatment of cancers that are linked to the human papilloma virus (HPV) oncoprotein E6, such as cervical cancer.
Certain viral oncoproteins, including HPV E6, are known to interfere with the function of a protein called p53, a key tumor suppressor involved in apoptosis. Loss of p53 is linked to uncontrolled cell proliferation, the hallmark of cancer, and is known to increase the resistance of tumor cells to some chemotherapeutic treatments. HPV is a major cause of cervical cancer, and earlier studies have suggested that interfering with E6 may lead to the death of E6-expressing cells. However, methods used to target E6 in these studies involved techniques that are not easily translatable to therapeutic use, and at this time, no specific therapies exist.
Dr. Brent R. Stockwell and colleagues from Columbia University designed a study to uncover small molecules that can overcome E6-induced drug resistance and which would be more easily adaptable to cancer treatment. The researchers used a screening method to look for compounds that potentiate chemotherapeutic effectiveness of the agent doxorubicin in E6-expressing colon cancer cells that are normally relatively resistant to the drug. "We identified several groups of compounds that potentiate doxorubicins lethality in E6-expressing tumor cells, thus overcoming E6-induced drug resistance," offers Dr. Stockwell.
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24.04.2017 | Indiana University
Two-dimensional melting of hard spheres experimentally unravelled after 60 years
24.04.2017 | University of Oxford
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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