Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a type of programmed cell death called apoptosis. A new study published in the February issue of Cancer Cell identifies compounds and mechanisms that can overcome a specific type of resistance to chemotherapeutic-induced apoptosis. The findings may have application for treatment of cancers that are linked to the human papilloma virus (HPV) oncoprotein E6, such as cervical cancer.
Certain viral oncoproteins, including HPV E6, are known to interfere with the function of a protein called p53, a key tumor suppressor involved in apoptosis. Loss of p53 is linked to uncontrolled cell proliferation, the hallmark of cancer, and is known to increase the resistance of tumor cells to some chemotherapeutic treatments. HPV is a major cause of cervical cancer, and earlier studies have suggested that interfering with E6 may lead to the death of E6-expressing cells. However, methods used to target E6 in these studies involved techniques that are not easily translatable to therapeutic use, and at this time, no specific therapies exist.
Dr. Brent R. Stockwell and colleagues from Columbia University designed a study to uncover small molecules that can overcome E6-induced drug resistance and which would be more easily adaptable to cancer treatment. The researchers used a screening method to look for compounds that potentiate chemotherapeutic effectiveness of the agent doxorubicin in E6-expressing colon cancer cells that are normally relatively resistant to the drug. "We identified several groups of compounds that potentiate doxorubicins lethality in E6-expressing tumor cells, thus overcoming E6-induced drug resistance," offers Dr. Stockwell.
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
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