Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Faults in newly discovered breast stem cells may lead to tumours

05.01.2006


Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using a mouse model, have discovered the rare stem cell that drives the formation of all breast tissue. This discovery lays an important foundation for understanding how normal breast tissue develops. The identification of the breast stem cell is also likely to provide clues about how breast cancer develops and how rogue cells evade current therapies.



Under normal circumstances, the newly identified breast stem cell will produce healthy tissue. But it is believed that an accumulation of genetic errors, perhaps combined with external influences and a family predisposition, could cause the breast stem cell or a "daughter" cell to produce faulty cells. In effect, the errant breast cell can become a tumour factory.

For many years, scientists and clinicians have been puzzled by the fact that women whose breast cancer cells have been apparently eliminated by chemotherapy sometimes experience a recurrence of their cancer. A cancerous stem cell could provide one possible explanation for such a recurrence.


Chemotherapy works by targeting cells that are dividing rapidly, which is typical behaviour of cancer cells. But an errant stem-like cell may be more resistant to chemotherapy because it divides more slowly. So while chemotherapy can eliminate the bulk of cancer cells, the tumour factory itself – a breast cancer stem cell – may survive months or years later.

In the context of international breast cancer research, the discovery of the breast stem cell is quite profound and will most likely form the basis of research in the area for years to come.

The ultimate objective is to create a drug that will, in effect, switch off breast cancer cells. To do this, the exact makeup of genes expressed by normal and rogue stem cells will need to be determined. Then a drug will be designed to engage with and neutralize the faulty feature of the stem cell.

Further research is now under way on excised human breast tumours to confirm the findings derived from the mouse model. The research team is from the WEHI Group of the Victorian Breast Cancer Research Consortium, which is funded by the Victorian state government through the Cancer Council Victoria.

Brad Allen | EurekAlert!
Further information:
http://www.researchaustralia.com.au/

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>