Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetics may affect how older adults respond to exercise

10.08.2005


New research suggests why some older adults who exercise have better physical function than others. Surprisingly, researchers found that an enzyme involved in blood pressure regulation may also influence how the body responds to exercise. The findings, by researchers at Wake Forest University School of Medicine and colleagues, are reported today in the Journal of the American Medical Association.



"Our results reinforce the importance of exercise, but also may explain a mechanism for why it seems to benefit some individuals more than others," said Stephen Kritchevsky, Ph.D., professor of gerontology at Wake Forest, who led the study.

The study is the first to show that a gene that controls levels of angiotensin converting enzyme (ACE) in the body may be associated with physical function in older adults.


The researchers found that older exercisers who inherited a gene combination associated with the lowest ACE production were 45 percent more likely to develop difficulties with climbing stairs or walking a quarter-mile than exercisers with gene combinations associated with higher levels of ACE.

"Overall, ACE genotype seems to be associated with how well activity helps preserve function," said Kritchevsky. "This finding may offer new opportunities to explore treatments to help older adults maintain their function."

The results are from the ongoing Health Aging and Body Composition Cohort Study, conducted in the metropolitan areas of Memphis, Tenn., and Pittsburgh, Pa. The study involves 3,075 well-functioning, community-dwelling adults ages 70 through 79. Participants were enrolled in 1997 and 1998.

The current data are from 2,966 participants who were followed for up to 4.1 years. About a third (31.3 percent) of the group was active, burning more than 1,000 calories a week in exercise; the others were inactive. The researchers found that the exercisers were significantly less likely (33 percent) to report mobility problems than the non-exercisers.

More than a third of adults in the United States who are 70 and older report having difficulty walking a quarter-mile or climbing 10 stairs. Previous research has shown that these mobility difficulties often proceed to physical disability. Older adults reporting these difficulties are at four times the risk of entering a nursing home and three times the risk of dying over a two-year period compared with those reporting no difficulty.

"Research has consistently found that exercise is associated with lower risk for physical decline," said Kritchevsky. "But despite exercise’s benefit, individual responses vary and our current findings about the ACE genotype may help explain why."

The same ACE gene combination associated with better function in exercising older adults has been associated with superior muscle strength and power in young elite athletes. The current study was designed to test whether ACE production also affects physical function in older exercisers.

The gene that controls ACE production can be inherited in three different combinations. Only about 19 percent of study participants had the combination associated with lower ACE production and did not benefit as much from exercise as others. However, they still did better than those who didn’t exercise.

"The results underscore the need to learn more about how the ACE system influences human health," Kritchevsky said.

Co-researchers are from Vrije Universtiteit (the Netherlands), National Institute on Aging, University of Pittsburgh, University of Tennessee, Memphis, University of Wisconsin - Madison, University of California-San Francisco, and University of Florida-Gainsville.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Life Sciences:

nachricht Hunting pathogens at full force
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung

nachricht A 155 carat diamond with 92 mm diameter
22.03.2017 | Universität Augsburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>