Using newly available biological technology, researchers have developed the first molecular portrait of multiple gene activity in diseased heart tissue taken from dogs near death from a devastating disease. The discovery sheds new light on the hearts response to dilated cardiomyopathy (DCM), a disease of large-breed dogs.
New microscopic technology allows researchers to place tens of thousands of genes on 1.5-inch-square slides known as a microarray. In this case, researchers used the GeneChip Canine Genome Array, a newly available commercial microarray specifically designed for dogs and containing more than 23,000 genes. With it, they performed global genome-expression profiling to focus on the transcription (the level of genetic coding into messenger RNA) of the genes taken from five healthy dogs and two Dobermans with DCM.
In the affected dogs, 478 transcripts were significantly different from those in the tissue of the control animals. Of these transcripts, 173 were increased (up regulated) while 305 were lowered (down regulated). From this pool, the researchers identified 167 genes that may play a role in the development and progression of DCM.
Jim Barlow | EurekAlert!
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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