Nerves talk to each other using chemicals called neurotransmitters. One of those "communication chemicals," aptly named GABA (gamma amino butyric acid), shows up in unusually high amounts in some aggressive tumors, according to a new study from Washington University School of Medicine in St. Louis.
The researchers investigated metastatic neuroendocrine tumors, which include aggressive types of lung, thyroid, and prostate cancers that spread to other parts of the body. Their study will appear in the July 12 issue of the Proceedings of the National Academy of Sciences and is available online after July 4.
"GABA appears to be an indicator of a bad prognosis for these cancers," says Jeffrey I. Gordon, M.D., director of the Center for Genome Sciences at Washington University. "But theres hope in our ability to identify substances, like GABA, that are associated with metastatic tumors. Usually these tumors are diagnosed only after they have spread to other parts of the body, but now we have the potential to recognize them before they metastasize."
Gwen Ericson | EurekAlert!
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