Scientists in the UK have proved that human embryonic stem cells can develop in the laboratory into the early forms of cells that eventually become eggs or sperm. Their work opens up the possibility that eggs and sperm could be grown from stem cells and used for assisted reproduction, therapeutic cloning and the creation of more stem cells for further research and for the improved treatments for patients suffering from a range of diseases.
Behrouz Aflatoonian will tell the 21st annual conference of the European Society of Human Reproduction and Embryology today (Monday 20 June) that the research also solves the practical and ethical problems associated with obtaining human samples of primordial germ cells (PGCs), which are the ancestral cells that eventually form eggs and sperm (gametes). “Investigating the mechanisms of human primordial germ cell and gamete development is important for understanding the causes of infertility and the potential harmful effects of environmental chemicals on reproductive development,” he will say. “But at present it is very difficult to obtain human samples of these cells as they only occur early in development.”
Mr Aflatoonian, who is a PhD student in Professor Harry Moore’s laboratory at the Centre for Stem Cell Biology, University of Sheffield, UK, said that studies with mice embryonic stem cells had shown that they were capable of differentiating into PGCs and subsequently eggs and sperm, so he set out to see if the same applied to human embryonic stem cells (HESCs).
Emma Mason | alfa
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy