Hormone affects females, males differently
University of Minnesota researchers have demonstrated for the first time how estrogen affects learning and memory. They found that estrogen can activate particular glutamate receptors within the hippocampus, the brain region responsible for many aspects of learning and memory. Glutamate is the primary excitatory neurotransmitter in the brain, allowing for fast communication between neurons. By examining hippocampal neurons from rats, researchers also observed that estrogen only activated the processes related to learning and memory in the brains of female rats and not males. While it has been well documented that estrogen influences other behaviors beyond reproduction, including learning and memory, the mechanism has remained elusive. The findings of this research are in this weeks Journal of Neuroscience.
"We believe this is an important first step in understanding not just how estrogen affects learning and memory, but also a variety of non-reproductive behaviors," says Paul Mermelstein, Ph.D., assistant professor of neuroscience at the University of Minnesota and lead researcher. "Estrogen activation of glutamate receptors within other brain regions could also potentially account for the well-documented actions of this hormone on female motor control and pain sensation."
Molly Portz | EurekAlert!
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