May help decipher regulator proteins’ roles in cell differentiation, cancer, and more
Finding out where gene-regulator proteins bind to DNA and identifying the genes they regulate just got a step easier thanks to a new technique developed by scientists at the U.S. Department of Energy’s Brookhaven National Laboratory. The technique could greatly speed the process of unraveling the role these proteins play in turning on and off the genes that establish the very identity of cells — be they brain cells, liver, or blood — as well as what might go awry in certain conditions like cancer.
The Brookhaven scientists, together with collaborators from Oregon Health & Science University, Emory School of Medicine, and Stony Brook University, have published the first results using their technique in the December 29, 2004 issue of Cell, where they describe the human-genome binding sites of a regulator protein known as CREB.
Karen McNulty Walsh | EurekAlert!
Further information:
http://www.bnl.gov
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