Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Discovery in Preventing Diabetic Complications

24.08.2004


A new study sheds light on the response to infection in people with type 2 diabetes. These individuals develop diabetes associated with obesity. Findings from this study revealed that controlling a specific protein produced by the body, known as a cytokine, reduces the expression of other molecules and helps control inflammation. This is significant because many complications associated with diabetes trigger an inflammatory response. Right now, type 2 diabetes affects over 17 million people in the United States and impacts the health industry significantly on economic and individual levels [1].

Tumor necrosis factor (TNF), a type of cytokine, can cause inflammation and damage [2] in soft tissue infections, bite wounds and in periodontal disease. In a recent study published in the Journal of Investigative Dermatology, two groups of lab mice, one normal, the other diabetic, were injected with anaerobic bacteria, a germ present in “approximately one-third of bite wounds and … associated with the formation of abscesses and with relatively serious infections,” [3,4] to determine how type 2 diabetes affects the inflammatory response in surrounding tissue. Results from the tests demonstrated that the presence of diabetes prolongs inflammation. Following infection, the normal mice were able to rapidly resolve the ensuing inflammation within three days whereas the diabetic mice could not.
“It may be particularly important in diabetics to consider the impact that prolonged inflammation might have on the course of events,” states contributing author Dr. Dana T. Graves. According to the study, diabetics are particularly susceptible to the detrimental effects of infection associated with inflammatory cytokines. Further, inflammation can often be a precursor to complications such as cardiovascular disease and poor wound healing. Dr. Graves concludes, “If excess TNF in diabetics is inhibited, the tendency for prolonged inflammation is reduced.”


1 American Diabetes Association, All About Diabetes, 2004
2 Gorman JD, et al: Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor a. New England Journal of Medicine, 346(18): 1349–1356, 2002
3 Edelman S: Importance of glucose control. Med Clin North Am 82:665-687, 1998
4 Zimmet P, Alberti K, Shaw J: Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001

Sharon Agsalda | alfa
Further information:
http://www.blackwellpublishing.com/jid

More articles from Life Sciences:

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Climate change: In their old age, trees still accumulate large quantities of carbon

17.08.2017 | Earth Sciences

Modern genetic sequencing tools give clearer picture of how corals are related

17.08.2017 | Life Sciences

Superconductivity research reveals potential new state of matter

17.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>