An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research. When ovarian tumors develop, however, the number of these receptors--known as estrogen receptor beta (ER beta)--diminishes, encouraging these tumors to advance toward malignancy and metastasis. This disappearing act may help explain why ovarian cancers are often typically resistant to anti-estrogen drugs including Tamoxifen.
"Ovarian cancer is remarkably lacking in response to antiestrogens such as Tamoxifen," Gwendal Lazennec, Ph.D., research group leader in molecular and cellular endocrinology of cancers at Inserm U540, Montpellier, France. "We hypothesized that this may be due to the selective decrease that we observed in the expression of message for ER beta in tumors from ovarian cancer patients."
Tumors from 58 ovarian cancer patients contained less messenger RNA for the ER beta than found in ovarian samples from healthy patients, said Lazennec, whose team included scientists from France and Italy. To understand how the loss of ER beta affected the ovarian cells during cancer progression, the gene for ER beta was replaced in ovarian cancer cell lines that no longer expressed the estrogen-triggered nuclear receptor. The ER beta reintroduced into the cancer cell lines did not share the classic functions attributed to estrogen receptors, including induction of progesterone receptor expression and fibuline-1C, and its ability to decrease the expression of the cyclin D1 gene was completely opposite of its counterpart, ER beta.
Russell Vanderboom, PhD | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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