Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A First Glance at the Gene Networks of Human Aging

30.07.2004


Scientists have rendered the first gene and protein networks of human aging, an important step in understanding the genetic mechanisms of aging. The work led by Joao Pedro de Magalhaes from Harvard Medical School is detailed in the July 30 issue of FEBS Letters.

The work involved the integration of all genes, in both humans and animal models, previously shown to influence aging. By using a combination of bibliographic information and modern high-throughput genomics, employing software developed by the team, each gene was placed in the context of human biology. The putative impact of each gene to human aging was calculated by a combination of manual and computational methods, leading to a new holistic view of the genetics of aging. To organize and catalog all the data pertaining the over 200 genes selected, the first curated database of genes related to human aging was developed: GenAge, part of the Human Ageing Genomic Resources also led by Dr. de Magalhaes. Thanks to the help of many other researchers, the Human Ageing Genomic Resources have become, in months, the landmark online website for research on aging, having been recently featured in Nature Reviews Genetics (volume 5, issue 5, page 330) and SAGE KE (2004 volume, issue 30, nf69), Science Magazine’s website on aging research.

With the collaboration of researchers from the University of Namur in Belgium, scientists also analyzed protein-interaction maps for more specialized pathways previously linked with aging, such as the neuroendocrine regulation of aging and DNA metabolism. These findings and the rendered networks related to aging may prove useful to find novel genes of interest. In fact, several crucial nodes in the networks were identified by way of specialized software: a number of genes so far not linked to aging were chosen by a “guilt-by-association” methodology based on protein-protein interaction maps and data-mining algorithms. One intriguing finding was the apparent overlap between the genetics of aging and development. Aging could then be an indirect result of developmental pathways. The cascade of events that regulates ontogeny would then fade away after sexual maturity resulting in aging. Contrary to other theories of aging that argue aging derives from the accumulation of damage, Dr. de Magalhaes suggests that integrative pathways collaborate during development and then become disrupted during aging.



The GenAge database will be in constant development since several genes involved in aging are certainly yet to be identified. Even so, it provides an overview of the current state-of-the-art knowledge on human aging. While much works remains to fully understand aging, this is a major first step in understanding the genetic mechanisms of human aging and provides a framework for future experimental verification.

Joao Magalhaes | alfa
Further information:
http://www.med.harvard.edu
http://genomics.senescence.info

More articles from Life Sciences:

nachricht Cnidarians remotely control bacteria
21.09.2017 | Christian-Albrechts-Universität zu Kiel

nachricht Immune cells may heal bleeding brain after strokes
21.09.2017 | NIH/National Institute of Neurological Disorders and Stroke

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Comet or asteroid? Hubble discovers that a unique object is a binary

21.09.2017 | Physics and Astronomy

Cnidarians remotely control bacteria

21.09.2017 | Life Sciences

Monitoring the heart's mitochondria to predict cardiac arrest?

21.09.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>