Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reveals gene linked to breast cancer can suppress tumors

29.07.2004


Finding identifies how estrogen-blocking ability of gene inhibits tumor growth

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women. The work also provides further evidence about how estrogen helps activate a disease that afflicts thousands of American women each year.

Dr. Ellis Levin, a professor of medicine, biochemistry and pharmacology at UCI, and colleagues at the Long Beach Veterans Administration Medical Center and Georgetown University Lombardi Cancer Center have identified how the healthy BRCA1 gene prevents the growth and survival of breast cancer cells. The gene accomplishes this by keeping estrogen and growth factor molecules from sending chemical messages through specific signaling pathways on the surface of breast cancer cells – signals that can cause a tumor to grow.



When the BRCA1 gene is mutated, however, it can no longer block this signaling activity from stimulating the growth and survival of cancer cells. The findings suggest that drugs developed to block estrogen signaling at these specific pathways can help curb the incidence of breast cancer in women. The study appears in the July issue of Molecular and Cellular Biology.

Levin said that the findings give further insight into how estrogen can interact with mutant BRCA1 to promote the development of breast cancer. This discovery is important, he added, because women who take estrogen supplements for more than five years to treat menopause symptoms increase their chances of developing breast cancer by about 25 percent.

“The therapeutic goal is to develop estrogen inhibitors that would prevent these types of undesirable effects, yet preserve the positive effects that prevent osteoporosis or hot flashes. Alternatively, enhancing or restoring normal BRCA1 protein function is another approach to consider in women with such BRCA1 mutations,” said Levin, who also is chief of endocrinology at UCI and at the VA Medical Center.

It has been long established that mutations in BRCA1 genes strongly increase the risk of breast and ovarian cancer in women and prostate cancer in men; up to 80 percent of women who have this mutated gene ultimately develop breast cancer. Healthy BRCA1 genes are involved with repairing DNA damage, promoting chromosome stability and regulating cell growth activity, but this study has identified a novel and potentially important role as a tumor suppressor. The researchers only studied the tumor-suppressing role of BRCA1 in breast cancer.

Mahnaz Razandi and Ali Pedram of UCI and Dr. Eliot Rosen of Georgetown assisted with the study. The Department of Veterans Affairs, Department of Defense, the National Institutes of Health, the Avon Products Breast Cancer Research Foundation and the Susan B. Komen Breast Cancer Foundation provided support.

Tom Vasich | EurekAlert!
Further information:
http://www.uci.edu

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>