Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reveals gene linked to breast cancer can suppress tumors

29.07.2004


Finding identifies how estrogen-blocking ability of gene inhibits tumor growth

A UC Irvine researcher has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer in women. The work also provides further evidence about how estrogen helps activate a disease that afflicts thousands of American women each year.

Dr. Ellis Levin, a professor of medicine, biochemistry and pharmacology at UCI, and colleagues at the Long Beach Veterans Administration Medical Center and Georgetown University Lombardi Cancer Center have identified how the healthy BRCA1 gene prevents the growth and survival of breast cancer cells. The gene accomplishes this by keeping estrogen and growth factor molecules from sending chemical messages through specific signaling pathways on the surface of breast cancer cells – signals that can cause a tumor to grow.



When the BRCA1 gene is mutated, however, it can no longer block this signaling activity from stimulating the growth and survival of cancer cells. The findings suggest that drugs developed to block estrogen signaling at these specific pathways can help curb the incidence of breast cancer in women. The study appears in the July issue of Molecular and Cellular Biology.

Levin said that the findings give further insight into how estrogen can interact with mutant BRCA1 to promote the development of breast cancer. This discovery is important, he added, because women who take estrogen supplements for more than five years to treat menopause symptoms increase their chances of developing breast cancer by about 25 percent.

“The therapeutic goal is to develop estrogen inhibitors that would prevent these types of undesirable effects, yet preserve the positive effects that prevent osteoporosis or hot flashes. Alternatively, enhancing or restoring normal BRCA1 protein function is another approach to consider in women with such BRCA1 mutations,” said Levin, who also is chief of endocrinology at UCI and at the VA Medical Center.

It has been long established that mutations in BRCA1 genes strongly increase the risk of breast and ovarian cancer in women and prostate cancer in men; up to 80 percent of women who have this mutated gene ultimately develop breast cancer. Healthy BRCA1 genes are involved with repairing DNA damage, promoting chromosome stability and regulating cell growth activity, but this study has identified a novel and potentially important role as a tumor suppressor. The researchers only studied the tumor-suppressing role of BRCA1 in breast cancer.

Mahnaz Razandi and Ali Pedram of UCI and Dr. Eliot Rosen of Georgetown assisted with the study. The Department of Veterans Affairs, Department of Defense, the National Institutes of Health, the Avon Products Breast Cancer Research Foundation and the Susan B. Komen Breast Cancer Foundation provided support.

Tom Vasich | EurekAlert!
Further information:
http://www.uci.edu

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>