Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saving Cells - Safer Method for Filtering Sensitive Biological Products

26.07.2004


For many years, engineers have worked to efficiently filter valuable bio-process products on an industrial economic scale. The challenge has been to push rates up without incurring high shear rates and resultant cell lysis, which would cause loss of yield. High shear can destroy delicate and valuable biological materials such as proteins, blood, algae and yeasts, and also brings with it a requirement for higher flow rates, which in turn raises pumping costs.



Inventors at the University of Oxford have developed two very elegant solutions to this dilemma, each of which would allow bio-process engineers to “have their cake and eat it” – i.e. achieve high flux AND low shear. Both technologies are improvements upon the existing practice of using ceramic block or tubular membrane filters, allowing users to obtain breakthrough performance without incurring massive disruption.

The first method is an insert that could be applied to existing tubular membrane filters (TMF) as an add-on. It can be used to achieve excellent mixing at low rates of flow and with a laminar flow pattern. This combination helps to minimise cell damage in the filtration of sensitive materials as high filtration fluxes are obtained at much lower feed flow rates than are currently achieved using existing equipment. The method has been successfully used for ultrafiltration of protein solutions with high flux and negligable fouling; separation of plasma from whole blood by microfiltration and separation of high concentration yeast suspensions. All of these important processes can be achieved more effectively at a much lower cost if the insert method is adopted.


The second method or "Helical Groove" ceramic block membrane filter would be a suitable replacement for an existing ceramic block filter element. Normally the performance of these filters is limited by the efficiency of fluid mixing. The helically grooved internal structure of the new membrane allows optimisation of radial mixing as the surface area of the filter is increased. The inherent properties of the filters are also important and include excellent chemical and thermal stability and rigidity. From a practical point of view they are easy to sterilise and can be easily adapted for use in large-scale units.

The inventions are now the subject of granted patents and a ten-tube microfiltration module is available for demonstration purposes. Companies interested in developing these systems for commercial applications should contact Isis Innovation Ltd.

Kim Bruty | alfa
Further information:
http://www.isis-innovation.com

More articles from Life Sciences:

nachricht Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo

nachricht Full of hot air and proud of it
18.04.2018 | University of Pittsburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

Im Focus: Stronger evidence for a weaker Atlantic overturning

The Atlantic overturning – one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards – is weaker today than any time before in more than 1000 years. Sea surface temperature data analysis provides new evidence that this major ocean circulation has slowed down by roughly 15 percent since the middle of the 20th century, according to a study published in the highly renowned journal Nature by an international team of scientists. Human-made climate change is a prime suspect for these worrying observations.

“We detected a specific pattern of ocean cooling south of Greenland and unusual warming off the US coast – which is highly characteristic for a slowdown of the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Improved stability of plastic light-emitting diodes

19.04.2018 | Power and Electrical Engineering

Enduring cold temperatures alters fat cell epigenetics

19.04.2018 | Life Sciences

New capabilities at NSLS-II set to advance materials science

18.04.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>