In experiments with fruit flies, Johns Hopkins researchers have discovered how a key light-detecting molecule in the eye moves in response to changes in light intensity. Their finding adds to growing evidence that some creatures -- and probably people -- adapt to light not only by mechanically shrinking the pupil to physically limit how much light enters the eye, but also by a chemical response.
Building on their previous work showing that specific proteins in eye cells are redistributed in response to bright light, the Johns Hopkins team now reports how a key protein called arrestin is shuttled from a "holding area" where it binds and calms a light-detecting protein. Writing in the July 7 issue of Neuron, the team says arrestin is moved around by a tiny molecular motor, called myosin, which travels along the "train tracks" of the cell’s internal skeleton.
Arrestin’s swift relocation, the researchers proposed, helps prevent temporary blindness that would otherwise be caused by a sudden increase in light intensity, such as occurs when stepping from a dark movie theater into the bright afternoon sunshine.
Maelstroms in the heart
22.02.2018 | Max-Planck-Institut für Dynamik und Selbstorganisation
Decoding the structure of the huntingtin protein
22.02.2018 | Max-Planck-Institut für Biochemie
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
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