Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rat kidneys and toad brains communicate in almost the same manner

07.05.2004


Dutch researcher Niels Cornelisse used computer models to study the electrochemical communication between cells from rat kidneys and cells from the pituitary gland of a toad species. He found many similarities in the coupling of chemical and electrical signals in these completely different cells.



Cells transmit electrical and chemical signals to other cells to coordinate the various cellular activities in the organism. Cornelisse made a mathematical model for the link between the chemical calcium signal and the electrical activity of brain cells. With this model he discovered many similarities between the linking of the electrical and chemical signals in a completely different cell type, the tissue cell, even though the cells studied had completely different functions.

Fundamental knowledge about the manner in which cells communicate with each other, could provide insights into diseases, such as cancer or brain disorders, where something goes wrong with the signal transfer between cells.


The brain cell originated from the pituitary gland of the African clawed frog (Xenopus laevis). This cell issues a hormone which regulates the colouration of the skin. This allows the toad to adjust its skin colour to the light intensity of its surroundings. The other cell type, the tissue cell, originated from the supportive tissue of rat kidneys.

Under certain experimental conditions, both cell types exhibit spontaneous electrical activity as well as associated spontaneous variations in the concentration of calcium ions in the cell. Calcium ions ensure the transfer of information within a cell and are, for example, involved in the emission of chemical signals, cell division and muscular contraction.

As well as the many similarities, the researcher also found an important difference in communication between the two cell types. In the toad cell, the link between the chemical calcium signal and the electrical signal was particularly important for initiating the spontaneous cell activity. However, in the rat cell, the link between the two signals mainly ensured the transmission of the calcium signal through a network of cells.

The research was funded by the Netherlands Organisation for Scientific Research.

Sonja Jacobs | NWO
Further information:
http://www.nwo.nl/nwohome.nsf/pages/NWOP_5XZDBJ_Eng

More articles from Life Sciences:

nachricht New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience

nachricht Wintering ducks connect isolated wetlands by dispersing plant seeds
22.02.2017 | Utrecht University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Positrons as a new tool for lithium ion battery research: Holes in the electrode

22.02.2017 | Power and Electrical Engineering

New insights into the information processing of motor neurons

22.02.2017 | Life Sciences

Healthy Hiking in Smart Socks

22.02.2017 | Innovative Products

VideoLinks
B2B-VideoLinks
More VideoLinks >>>