Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MGH research team grows long-lasting blood vessels

11.03.2004


Advance could solve major challenge in tissue engineering



Researchers from Massachusetts General Hospital (MGH) have successfully induced the growth of new networks of functional blood vessels in mice. In the March 11 issue of Nature, the team from the Steele Laboratory in the MGH Department of Radiation Therapy describes how their technique led to the growth of long-lasting blood vessels without the need for genetic manipulation. The accomplishment may help solve one of the primary challenges in tissue engineering: providing a blood supply for newly grown organs.
"The biggest challenge has been making blood vessels that will last," says Rakesh Jain, PhD, director of the Steele Laboratory and senior author of the Nature report. "Most artificially grown vessels die quickly, but these have survived successfully for a year – which is about half a lifetime for mice." He and his colleagues also note that the introduction of genes to induce vessel growth and survival could increase the risk of cancer.

The research team began with two types of blood-vessel-related human cells – endothelial cells that form the lining of blood vessels, taken from the veins of umbilical cords, and precursors to the perivascular cells that form the supporting outer layer of blood vessels. These cells were placed into a collagen gel and grown in culture for about a day. Then the gels were implanted into cranial windows, transparent compartments placed on the brains of mice. Similar gels containing only endothelial cells were also prepared and implanted.



Within a few days both types of implants began to form long, branched tubes. Tubes in the endothelial/perivascular cell implants soon connected to the mice’s own vessels and began to carry blood. They grew rapidly for about two weeks, and then reached a point of stability. However, implants containing only endothelial cells showed little or no connection to the mouse vasculature, and within two months the new vessels in those implants almost completely disappeared.

"The combined implants formed beautiful networks that survived and grew," Jain says. "As they matured, they appeared and functioned very much like normal vasculature tissue." Jain is Cook Professor of Tumor Biology at Harvard Medical School.

The researchers believe their technique could eventually allow the growth of new blood vessels from a potential recipient’s own cells and could also be a model system for future studies of vessel growth and maturation.


The study’s co-authors are Naoto Koike, MD, PhD; Dai Fukumura, MD, PhD; Oliver Gralla, MD, and Patrick Au, all of the Steele Laboratory; and Jeffrey Schechner, MD, of Yale School of Medicine. The research was partially supported by the National Cancer Institute.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $400 million and major research centers in AIDS, cardiovascular research, cancer, cutaneous biology, medical imaging, neurodegenerative disorders, transplantation biology and photomedicine. In 1994, MGH and Brigham and Women’s Hospital joined to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups, and nonacute and home health services.

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu/

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>