Scientists have identified a gene in mice that is necessary for normal brain development and may contribute to the most common form of primary brain tumors in children.
Dr. Valeri Vasioukhin and colleagues at the Fred Hutchinson Cancer Research Center have discovered that a gene known as "lethal giant larvae 1" (a.k.a. Lgl1) plays a critical role in shaping cell behavior during embryonic brain development. Lgl1 was initially identified in the fruit fly Drosophila, where it regulates cell polarity (the overall directionality of a cell) as well as cell proliferation. Dr. Vasioukhin and colleagues now show a similarly important role for Lgl1 in the mammalian brain.
To gain insight into Lgl1 function in mammals, Dr. Vasioukhin and colleagues generated mice specifically lacking the Lgl1 gene. These Lgl1-knockout mice – as they are known – developed normally at first, but by day 12.5 of gestation exhibited dramatic abnormalities. Lgl1-mutant pups have a dome-shaped head, severe hydrocephaly and die within 24 hours after birth. Internally, there is an expansion of the striatum region of the brain, along with the formation of abnormal cell groupings called rosettes.
Heather Cosel | EurekAlert!
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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