In the world of molecules, DNA tends to get top billing at the expense of RNA, which is critical for turning DNAs genetic blueprint into working proteins. Researchers at the Stanford University School of Medicine have published significant insights into how the RNA molecule completes this task in two back-to-back papers in the Feb. 13 issue of Science.
All the genetic information contained in DNA is silent, said Roger Kornberg, PhD, the Mrs. George A. Wizner Professor in Medicine and professor of structural biology. What gives it a voice is RNA polymerase, the enzyme that copies DNA into RNA through a process called transcription. Along with more than a dozen helper molecules, RNA polymerase determines which proteins are produced within a cell. But before scientists can understand the transcription process, they must first unveil the inner structure of RNA polymerase.
Kornbergs lab has been studying RNA and the enzyme that makes it for more than 20 years. Past studies from the lab have shown that the machinery of the RNA polymerase system is in three layers. Kornbergs group published groundbreaking findings in 2001 outlining the structure of the innermost layer. The two current papers focus on the middle layer, which contains many of the helper molecules.
Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy