Predisposition to many common diseases – among which cancer, cardiovascular conditions, diabetes, asthma, etc. – is said to be a multifactor phenomenon as it results from numerous genes as well as environmental factors. Identifying such predisposition genes is one of the major challenges in modern genetics and could contribute to establishing new preventive medicine patterns and developing new specific drugs.
However, the identification of predisposition genes appeared to be extremely difficult in humans. Despite huge investments, “successes” can be counted on the fingers of one hand.
Considering our domestic animals’ history, such populations are particularly well-adapted to the analysis of multifactor characters. This was shown most dramatically by the recent identification of a mutation in an IGF2 gene regulatory element leading to a muscle mass increase in pigs. A particularly ingenious genetic analysis allowed experts to isolate the relevant mutation among 280 other mutations identified in the gene. Functional analyses subsequently indicated that the mutation inactivated an inhibitor of the IGF2 production in muscles. As a consequence, it increased IGF2 secretion and muscle growth.
Didier Moreau | alfa
Signaling Pathways to the Nucleus
19.03.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
In monogamous species, a compatible partner is more important than an ornamented one
19.03.2018 | Max-Planck-Institut für Ornithologie
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
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19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News