Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stowers Institute researchers identify stem cell niche

23.10.2003


A research team led by scientists at the Stowers Institute for Medical Research have discovered the location in mice where hematopoietic stem cells (HSCs) reside, often called the HSCs’ microenvironment or "niche." The team also identified mechanisms involved in controlling the size of the niche and the number of adult HSCs the body produces. This research has solved the puzzle of the hematopoietic stem cell niche first articulated more than 25 years ago and has defined its essential features in both cellular and molecular terms.



The findings are reported in the Oct. 23 issue of Nature.

HSCs are a population of bone marrow cells capable of self-renewal and production of all types of blood cells. Normally these cells cannot function properly outside their exclusive niche. According to Stowers Institute Assistant Investigator Linheng Li, Ph.D., who led the study, the niche not only provides a home for the HSCs but also regulates their numbers. Gaining greater understanding of the stem cell’s niche and its regulatory signals is an important advance toward the goal of using stem cells for therapeutic purposes.


The research team found that a particular subset of osteoblastic cells, called SNO (spindle-shaped N-cadherin-positive osteoblastic) cells, line the surface of trabecular bone in the marrow cavity, support hematopoietic stem cells, and constitute the primary cellular component of the niche where HSCs reside. By interrupting the signaling pathway through the bone morphogenetic protein (BMP) receptor, the team showed that the size of the HSC niche and the number of HSCs could be increased. They concluded that a change in the size of this niche determines the number of stem cells produced, and the BMP signaling pathway controls the niche size and thus the number of stem cells.

"Although we have identified the SNO cells as an important cellular component of the HSC niche, whether SNO cells alone are sufficient to maintain HSCs, particularly in vitro, is not clear at this point," Dr. Li said. "This merits further investigation."

Dr. Li’s findings are corroborated in studies undertaken independently by a group of scientists working at the University of Rochester and at Harvard Medical School and published simultaneously in the October 23 issue of Nature.

"Jim and Virginia Stowers believe that highest quality basic research will point the way to more effective means of preventing and curing disease," said William Neaves, Ph.D., President and CEO of the Stowers Institute. "The work published by Dr. Li and his colleagues in the October 23 issue of Nature typifies the results envisioned by them. His findings open new opportunities for research on the stem cell niche and could eventually lead to more effective methods of restoring stem cells in the bone marrow of cancer patients after radiation and chemotherapy."

Joining Stowers Institute scientists in conducting the study were researchers from the University of Missouri-Kansas City School of Dentistry and the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. In addition to his primary appointment at the Stowers Institute, Dr. Li holds a faculty appointment at the University of Kansas School of Medicine.


Situated on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts research on the fundamental processes of cellular life. Through basic research of the highest quality, the Stowers Institute seeks insights that will lead to more effective ways of preserving health and preventing disease. The Institute was founded in 1994 by Jim and Virginia Stowers, two cancer survivors who have dedicated their fortune to supporting the basic research that will provide long-term solutions to gene-based diseases.

Laurie Wimberly | EurekAlert!
Further information:
http://www.stowers-institute.org/

More articles from Life Sciences:

nachricht Closing the carbon loop
08.12.2016 | University of Pittsburgh

nachricht Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>