A research team led by scientists at the Stowers Institute for Medical Research have discovered the location in mice where hematopoietic stem cells (HSCs) reside, often called the HSCs microenvironment or "niche." The team also identified mechanisms involved in controlling the size of the niche and the number of adult HSCs the body produces. This research has solved the puzzle of the hematopoietic stem cell niche first articulated more than 25 years ago and has defined its essential features in both cellular and molecular terms.
The findings are reported in the Oct. 23 issue of Nature.
HSCs are a population of bone marrow cells capable of self-renewal and production of all types of blood cells. Normally these cells cannot function properly outside their exclusive niche. According to Stowers Institute Assistant Investigator Linheng Li, Ph.D., who led the study, the niche not only provides a home for the HSCs but also regulates their numbers. Gaining greater understanding of the stem cells niche and its regulatory signals is an important advance toward the goal of using stem cells for therapeutic purposes.
Laurie Wimberly | EurekAlert!
Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY
Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center
A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Physics and Astronomy
24.01.2017 | Life Sciences
24.01.2017 | Health and Medicine