A California research team has mapped an entire group of human enzymes, providing important information for the development of a new generation of drugs to treat cancer and other diseases. The findings will be published in the Dec. 6 issue of Science.
In the study, the team from the Salk Institute for Biological Studies and the biotechnology company SUGEN created a detailed catalog of the 518 protein kinase genes encoded by the human genome. Protein kinases are among the most important regulators of cell behavior. By chemically adding phosphate groups to other proteins, they control the activity of up to 30 percent of all cellular proteins, and are involved in almost all cellular functions. They are especially important in sending signals between and within cells, and in orchestrating complex functions such as cell division. Overactive kinases are the cause of some types of cancer, and the central role of kinases in controlling cell behavior has led to their being investigated as targets for treatment of a variety of other diseases, including diabetes, osteoporosis, inflammation and occular diseases.
Scientists in academia and pharmaceutical companies have intensively studied the role of kinases in basic biology and in disease for many years, and several drugs targeting kinases are under development. These drugs may offer an alternative treatment to standard chemotherapy for the treatment of specific kinds of cancer. The recently approved anti-cancer drug Gleevec™, which is proving successful in treating chronic myeloid leukemia, is the first example of a small molecule kinase inhibitor drug of this sort.
Robert Bradford | EurekAlert!
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
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14.10.2016 | Event News
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