Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene found that helps nerve cells survive by preventing cell suicide

26.09.2002


Finding may lead to new treatments for neurologic disease and nerve injury



Why do some nerve cells survive and regrow after injury while others shrink away and die? A new discovery by researchers at Massachusetts General Hospital (MGH) shows that the expression of a particular gene may be responsible for protecting neurons from death. The results, published in the September 26 issue of Neuron, could lead the way for new treatment strategies for a variety of neurological diseases.

"Turning on the gene named Hsp27 could potentially rescue nerve cells in patients with neurodegenerative conditions such as Lou Gehrig’s disease," says principal investigator Clifford Woolf, MD, PhD, of the Neural Plasticity Research Group in the Department of Anesthesia and Critical Care at MGH.


Woolf and his colleagues found that young sensory and motor nerve cells die after injury because the heat shock protein 27 gene (Hsp27) is not turned on in these cells. In adult cells however, the gene is expressed. The resulting protein that is produced protects these mature nerve cells from death following an injury.

"As part of normal development, many more neurons are made than are needed," says Woolf, who also is Richard J. Kitz Professor of Anesthesia Research at Harvard Medical School. "So some must be pruned away by essentially committing cell suicide, a phenomenon known as programmed cell death. It seems that Hsp27 is turned off to allow for this normal developmental process."

Woolf explains that once an individual reaches adulthood, nerve cells in the body are permanent and irreplaceable. "That’s why it’s important to have a repair mechanism for older neurons," he says. The protein made by the Hsp27 gene blocks cell suicide from taking place following injury, rescuing injured cells. For example, cells expressing the Hsp27 protein acquire resistance to excessive heat, chemical stress, and toxins. Hsp27 directly inhibits the cellular proteins that trigger programmed cell death.

In laboratory dishes and in rat models, Woolf and his team showed that, if the Hsp27 gene is delivered to young nerve cells using gene therapy with viral vectors, the cells are able to survive injury just as well as older nerve cells. Equally, if the gene is switched off in adults, those cells will die. "Hopefully, therapy that prevents cell death by delivering genes like Hsp27 will someday find its way into the clinic," says Woolf. "Patients with Lou Gehrig’s disease, for example, suffer a progressive death of their motor neurons leading to paralysis. If Hsp27 were able to prevent the death of the neurons in these patients, it would offer the possibility of new therapy, something we plan to test"

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu/

More articles from Life Sciences:

nachricht New mechanisms uncovered explaining frost tolerance in plants
26.09.2016 | Technische Universität München

nachricht Chains of nanogold – forged with atomic precision
23.09.2016 | Suomen Akatemia (Academy of Finland)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

Stronger turbine blades with molybdenum silicides

26.09.2016 | Materials Sciences

Scientists Find Twisting 3-D Raceway for Electrons in Nanoscale Crystal Slices

26.09.2016 | Materials Sciences

Lowering the Heat Makes New Materials Possible While Saving Energy

26.09.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>