An international team of scientists led by researchers at The Wistar Institute has combined two different imaging techniques to uncover the molecular-level framework of a common bacteriophage, a virus that infects bacteria. The results, reported in the October issue of Nature Structural Biology, suggest that viruses developed a continuum of progressively more complex architectural strategies to cope with their increasing size as they evolved. An image from the study is featured on the journals cover.
The new findings may open a novel approach to developing therapies for certain difficult-to-treat infections. The bacteriophage studied, called PRD1, infects antibiotic-resistant strains of E. coli bacteria, including strains responsible for tens of thousands of cases of food poisoning in the United States each year. The intimate knowledge of PRD1s structure provided by the current study might help scientists develop a treatment for E. coli infections involving PRD1.
The structural details show that the bacteriophage has similarities to viruses smaller than itself, simple plant and animal viruses whose outer coats are formed from proteins held together by linked "arms." In addition, however, it also uses small "glue" proteins to cement larger proteins together. This feature makes it more like the human adenoviruses, larger and more complex viruses that infect the respiratory tract and cause other diseases. Taken together, these features place the bacteriophage at an intermediate point on the viral evolutionary tree and help illuminate the overall evolutionary path taken by families of viruses.
Franklin Hoke | EurekAlert!
Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
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