An international team of scientists led by researchers at The Wistar Institute has combined two different imaging techniques to uncover the molecular-level framework of a common bacteriophage, a virus that infects bacteria. The results, reported in the October issue of Nature Structural Biology, suggest that viruses developed a continuum of progressively more complex architectural strategies to cope with their increasing size as they evolved. An image from the study is featured on the journals cover.
The new findings may open a novel approach to developing therapies for certain difficult-to-treat infections. The bacteriophage studied, called PRD1, infects antibiotic-resistant strains of E. coli bacteria, including strains responsible for tens of thousands of cases of food poisoning in the United States each year. The intimate knowledge of PRD1s structure provided by the current study might help scientists develop a treatment for E. coli infections involving PRD1.
The structural details show that the bacteriophage has similarities to viruses smaller than itself, simple plant and animal viruses whose outer coats are formed from proteins held together by linked "arms." In addition, however, it also uses small "glue" proteins to cement larger proteins together. This feature makes it more like the human adenoviruses, larger and more complex viruses that infect the respiratory tract and cause other diseases. Taken together, these features place the bacteriophage at an intermediate point on the viral evolutionary tree and help illuminate the overall evolutionary path taken by families of viruses.
Franklin Hoke | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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