Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Do You Want Fries with That, Mickey? Gene Expression Differences in Mice Fed Human and Chimp Diets

30.01.2008
Using mice as models, researchers at the Max Planck Institute for Evolutionary Anthropology traced some of the differences between humans and chimpanzees to differences in our diet. The findings appear in the January 30 issue of PLoS ONE.

Humans consume a distinct diet compared to other apes. Not only do we consume much more meat and fat, but we also cook our food. It has been hypothesized that adopting these dietary patterns played a key role during human evolution. However, to date, the influence of diet on the physiological and genetic differences between humans and other apes has not been widely examined.

By feeding laboratory mice different human and chimp diets over a mere two week period, researchers at the Max-Planck-Institute for Evolutionary Anthropology in Leipzig, Germany, were able to reconstruct some of the physiological and genetic differences observed between humans and chimpanzees.

The researchers fed laboratory mice one of three diets: a raw fruit and vegetable diet fed to chimpanzees in zoos, a human diet consisting of food served at the Institute cafeteria or a pure fast food menu from the local McDonald's™ (the latter caused the mice to significantly gain weight). The chimpanzee diet was clearly distinct from the two human diets in its effect on the liver - thousands of differences were observed in the levels at which genes were expressed in the mouse livers. No such differences were observed in the mouse brains. A significant fraction of the genes that changed in the mouse livers, had previously been observed as different between humans and chimpanzees. This indicates that the differences observed in these particular genes might be caused by the difference in human and chimpanzee diets.

... more about:
»Chimpanzee »difference »genes »liver »observed

Furthermore, the diet-related genes also appear to have evolved faster than other genes - protein and promoter sequences of these genes changed faster than expected, possibly because of adaptation to new diets.

Contact:
Mehmet Somel
Email: somel@eva.mpg.de
Svante Pääbo
Email: paabo@eva.mpg.de
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Citation: Somel M, Creely H, Franz H, Mueller U, Lachmann M, et al (2008) Human and Chimpanzee Gene Expression Differences Replicated in Mice Fed Different Diets. PLoS ONE 3(1): e1504. doi:10.1371/journal.pone.0001504

Andrew Hyde | alfa
Further information:
http://www.plosone.org/doi/pone.0001504

Further reports about: Chimpanzee difference genes liver observed

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>