Researchers confirm genetic alteration that triggers prostate cancer in mice and man

Their findings will be published Jan. 28 in the online early edition of the Proceedings of the National Academy of Sciences.

A significant proportion of human prostate cancers carry a chromosomal rearrangement that results in the overexpression of the ETS transcription factor ERG, a protein that controls gene expression. Until now, the functional significance of this event has been poorly understood.

Studying prostate cells in transgenic mice, Vasioukhin, Nelson and colleagues at the Hutchinson Center and the University of Washington found that up-regulation of ERG transcript initiates cancer growth. They found a similar effect in human prostate cells. They hypothesize that up-regulation of ERG in human prostate cancer activates cell-invasion programs, causing the displacement of basal cells by neoplastic epithelium, or cancerous tissue.

As such, they suggest that ERG should be considered as a target for prostate-cancer prevention or early therapeutic intervention.

Media Contact

Kristen Woodward EurekAlert!

More Information:

http://www.fhcrc.org

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Better magnets for green energy

Researchers use multicomponent alloys to make strong and ductile soft magnetic materials. Latest results now published in the journal Nature. Soft magnetic materials (SMMs) applied in electric engines transform energy…

Sound plus electrical body stimulation has potential to treat chronic pain

New technique could relieve pain for individuals with various chronic and neurological conditions. A University of Minnesota Twin Cities-led team has found that electrical stimulation of the body combined with…

Bioengineered cornea can restore sight to the blind and visually impaired

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts. Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which…

Partners & Sponsors