Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pourquié lab links beta-catenin gradient to process of somite formation

03.01.2008
The Stowers Institute’s Pourquié Lab has demonstrated the importance of Beta-catenin, a key component of the Wnt-signaling pathway in the process of somite formation. The work has been published on the Web site of Nature Cell Biology and will appear in a future print issued. It was conducted using a novel real-time imaging technology.

The team analyzed the somite segmentation process that results in the formation of the vertebral column. This process is thought to be controlled by two components: a molecular oscillator (the segmentation clock), and the graded activity of several major signaling pathways (the gradient) in the presomitic mesoderm (PSM). The PSM is the middle layer of the three cell layers that form an early embryo. Wnt-signaling has been implicated in both these mechanisms, but precisely how was unclear until now.

In this work, the Pourquié team tested the importance of Beta-catenin, a protein that functions as the principal mediator of the Wnt-signaling pathway, in the process of somite formation. They showed that a newly identified Beta-catenin protein gradient in the PSM is critical in regulating mesoderm maturation. Real-time imaging experiments also demonstrated that, conversely, the segmentation clock is not caused by graded levels of Beta-catenin protein.

“We were able to demonstrate that increasing Beta-catenin protein levels dramatically alters PSM maturation,” said Alexander Aulehla, M.D., Senior Research Associate and first author on the paper. “But, by using the real-time imaging technique in mouse embryos, we could show that increasing Beta-catenin also corresponded with ongoing, even ectopic, oscillations of the segmentation clock, which controls the rate of somite development.”

“This work offers novel insights into how the mechanisms of maturation and oscillation in the PSM are controlled and how they are interconnected,” said Olivier Pourquié, Ph.D., Investigator and senior author on the paper. “Additionally, this project has allowed us to achieve the longstanding goal of visualizing the segmentation clock in real-time using fluorescence-based imaging, which is sure to impact other important projects in our lab”

Since joining the Stowers Institute in 2002, the Pourquié Lab has made a number of significant discoveries related to somite development. Somites eventually give rise to the vertebral column, which is malformed in people born with congenital scoliosis. It is believed that some cases of congenital scoliosis are caused by mutations related to the segmentation clock.

Marie Jennings | EurekAlert!
Further information:
http://www.stowers-institute.org
http://www.stowers-institute.org/labs/PourquieLab.asp

Further reports about: Beta-Catenin Gradient PSM Pourquié segmentation somite

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>