BPA, DES and similar compounds are known as endocrine-disrupting chemicals, which are substances in the environment that interfere with the proper functioning of hormones. This disruption results in adverse developmental, reproductive, neurological and immune effects in both humans and wildlife.
BPA is a weak estrogen and DES is a strong estrogen, but both have a profound effect on gene expression in the breast throughout life, according to lead author of the study Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. Taylor and his colleagues treated pregnant mice with BPA or DES and then studied the adult offspring. They found that the mammary glands in these offspring produce higher levels of EZH2, a protein that controls the expression of all genes. Higher EZH2 levels are associated with an increased risk of breast cancer in humans. The team demonstrated a mechanism by which endocrine-disrupting chemicals regulate developmental programming in the breast.
"These results show that all estrogens, even weak ones can alter the development of the breast and place our children at risk," said Taylor, who is also a member of Yale Cancer Center. "We many not be able to see the final effects of these exposures until our children reach the age when breast cancers start to appear."
"The data, coupled with our data on DES and BPA effects on the uterus, clearly demonstrate a lasting effect of prenatal exposure to estrogens on the breast and uterus," Taylor added. "This study generates important safety concerns about exposures to environmental endocrine disruptors such as BPA and suggests a potential need to monitor women exposed to these chemicals for the development of breast lesions as adults."
Other Yale authors on the study include Leo Doherty, Jason Bromer, Yuping Zhou and Tamir Aldad.
Citation: Hormones and Cancer doi: 10.1007/s12672-010-0015-9
Karen N. Peart | EurekAlert!
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
16.01.2018 | Materials Sciences
16.01.2018 | Materials Sciences
16.01.2018 | Power and Electrical Engineering