The influence of the majority of the new genes is independent of other established risk factors, suggesting new, unsuspected causes of CAD. The discovery more than doubles the number of genes known to affect the progression of heart disease.
The research also verified the association of 10 previously identified genes to the population at large, meaning their influence is not confined to a specific population. Of the 23 genes discovered or confirmed, only 6 could be linked to known risk factors such as cholesterol and high blood pressure, underscoring the direct and indirect role that genes play in influencing the course and evolution of heart disease.
"This is a landmark result because we have identified so many genes and most operate using completely unknown mechanisms to us right now," said Dr. Robert Roberts, President and CEO, University of Ottawa Heart Institute. "It has opened up significant new avenues for new therapies and underlines the complexities of heart disease."
These discoveries were published online today in Nature Genetics by one of the world's largest consortiums examining the genetic basis of heart disease. More than 100 research organizations took part in the study, including such internationally-acclaimed centres as the University of Lubeck (Germany), Stanford University, Harvard Medical School, University of Iceland, Johns Hopkins University, University of Leeds (UK), Wellcome Trust Sanger Institute, the University of Ottawa Heart Institute and others.
The study is also one of the world's largest. Called CARDIoGRAM (Coronary Artery Disease Genome-wide Replication and Meta-Analysis), researchers evaluated the genetic samples of more than 140,000 people of European descent, of which one third exhibited heart disease and the remainder (the control group) did not. Data from genetic research centres in Europe, the United Kingdom, the United States and the Heart Institute were combined to provide the massive sample size, which is essential to ferret out subtle genetic indicators.
"The consortium examined more than 10 times the number of samples than the largest study ever published, so we magnified the power to detect small genetic variations," said Dr. Roberts. "Now our job is to understand how these genes work, develop a new group of drugs to target them and identify people who will benefit most to reduce their risk of heart attack and other cardiac events."
"Our main aim of this extremely large study is to locate and examine new disease mechanisms and improve our means of preventing cardiovascular disease," said Dr. Thomas Quertermous, Professor of Cardiovascular Medicine, Stanford University, which participated in the research.
The Heart Institute's contributions to the consortium were led by the Institute's Ruddy Canadian Cardiovascular Genetics Centre. The Ruddy Centre is the only one of its type in Canada and only one of a handful of cardiovascular genetics research centres worldwide. The Ruddy Centre's scientific team included the director and principal investigator, Dr. Roberts, laboratory director Alexandre Stewart, PhD, biostatistician George A. Wells, and Dr. Ruth McPherson, an endocrinologist and molecular biologist.
The CARDIoGRAM study is the latest significant progress to emerge from the Heart Institute. The Institute previously identified gene 9p21 which was the first genetic risk factor recognized for heart disease and the first major new cardiovascular risk factor since the discovery of cholesterol. The Institute has also located a variety of other genes influencing diseases such as atrial fibrillation and biological processes such as obesity.
Research has shown that up to 40% of heart disease can be prevented by modifying cholesterol, high blood pressure, smoking and other lifestyle causes. At the same time, it is known that about 50% of the risk of heart disease is due to genetic factors. Comprehensive prevention programs are needed that not only deal with lifestyle issues but also address the genetic aspects of heart disease. When this occurs, it is believed that heart disease will be dramatically reduced or possibly eliminated within 50 years.
The University of Ottawa Heart Institute is Canada's largest and foremost cardiovascular health centre dedicated to understanding, treating and preventing heart disease. We deliver high-tech care with a personal touch, shape the way cardiovascular medicine is practiced, and revolutionize cardiac treatment and understanding. We build knowledge through research and translate discoveries into advanced care. We serve the local, national and international community, and are pioneering a new era in heart health. For more information, visit www.ottawaheart.ca
Editor: For more information on CARDIoGRAM, please visit http://www.nature.com/genetics/index.html
Marlene Orton | EurekAlert!
20.11.2017 | Washington University in St. Louis
Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
20.11.2017 | Earth Sciences
20.11.2017 | Earth Sciences
20.11.2017 | Life Sciences