Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genome-wide studies have identified new genes involved in susceptibility to melanoma

11.10.2011
The results are published in 2 Nature Genetics papers involving investigators from IDIBAPS -- Hospital Clínic of Barcelona

The genomic analysis technologies enable the study of genetic factors related to numerous diseases. In few areas this researches brought such a big and useful volume of information as in the case of melanoma.

A study published in Nature Genetics, promoted by the GenoMEL consortium, consolidates the results obtained in previous whole-genome analysis and identifies three new chromosomal regions implicated in susceptibility to melanoma. The GenoMEL consortium is funded by the European Commission and the National Institutes of Health (USA) to increase the understanding of genetic and molecular determinants of melanoma. Researchers at the Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and the Hospital Clínic of Barcelona have a relevant role among the promoters of this consortium led by the University of Leeds. Dr. Susana Puig leads the research team, formed by many experts as Dr. Josep Malvehy or Dr. Joan Anton Puig, and appears as an author in this Nature Genetics paper as well as in another one led from Australia. This team is supported by the CIBER of Rare Diseases (CIBERER) funded by the Spanish Ministry of Science and Innovation.

The conclusions of the European study revalidate regions and genes already identified as significant for melanoma in previous works. Thus the role of genes related to cell cycle as CDKN2A or CDK4, and other related aspects such as hair and eye pigmentation, is reinforced by the new data. The results identify too three new correlations with the risk of melanoma, located in different parts of the genome. On chromosome 2 investigators underline the role of Caspase 8, a gene related to programmed cell death or apoptosis; on chromosome 11 they localized ATM gene, linked to DNA repair, a necessary process specially after sunlight harmful effects overexposure; finally, the surprise was located on chromosome 21, where the MX2 gene was associated for the very first time with cancer and should be studied more carefully to understand its role.

The Australian work identified a large area of chromosome 1 rich with genes that might also be associated with melanoma. The relevance of these two works, both with the participation of researchers from IDIBAPS - Hospital Clínic, is reinforced by the fact that the results have been validated both in the European and Australian populations. Thus, the identified genes are relevant to the disease regardless of the population under study. Researchers face a complex puzzle, where environmental factors also play an important role. These data should aid studies aimed at designing new diagnostic and prognostic tools to make possible new treatments as well as to strengthen existing genetic counseling and diagnostic strategies.

For further information:
Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
IDIBAPS Communication
Àlex Argemí (aargemi@clinic.ub.es)
Tel: +34 93 227 57 00
www.idibaps.org

Alex Argemi | EurekAlert!
Further information:
http://www.idibaps.org

More articles from Life Sciences:

nachricht A room with a view - or how cultural differences matter in room size perception
25.04.2017 | Max-Planck-Institut für biologische Kybernetik

nachricht Studying a catalyst for blood cancers
25.04.2017 | University of Miami Miller School of Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Early organic carbon got deep burial in mantle

25.04.2017 | Earth Sciences

A room with a view - or how cultural differences matter in room size perception

25.04.2017 | Life Sciences

Warm winds: New insight into what weakens Antarctic ice shelves

25.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>