Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genome-wide studies have identified new genes involved in susceptibility to melanoma

11.10.2011
The results are published in 2 Nature Genetics papers involving investigators from IDIBAPS -- Hospital Clínic of Barcelona

The genomic analysis technologies enable the study of genetic factors related to numerous diseases. In few areas this researches brought such a big and useful volume of information as in the case of melanoma.

A study published in Nature Genetics, promoted by the GenoMEL consortium, consolidates the results obtained in previous whole-genome analysis and identifies three new chromosomal regions implicated in susceptibility to melanoma. The GenoMEL consortium is funded by the European Commission and the National Institutes of Health (USA) to increase the understanding of genetic and molecular determinants of melanoma. Researchers at the Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and the Hospital Clínic of Barcelona have a relevant role among the promoters of this consortium led by the University of Leeds. Dr. Susana Puig leads the research team, formed by many experts as Dr. Josep Malvehy or Dr. Joan Anton Puig, and appears as an author in this Nature Genetics paper as well as in another one led from Australia. This team is supported by the CIBER of Rare Diseases (CIBERER) funded by the Spanish Ministry of Science and Innovation.

The conclusions of the European study revalidate regions and genes already identified as significant for melanoma in previous works. Thus the role of genes related to cell cycle as CDKN2A or CDK4, and other related aspects such as hair and eye pigmentation, is reinforced by the new data. The results identify too three new correlations with the risk of melanoma, located in different parts of the genome. On chromosome 2 investigators underline the role of Caspase 8, a gene related to programmed cell death or apoptosis; on chromosome 11 they localized ATM gene, linked to DNA repair, a necessary process specially after sunlight harmful effects overexposure; finally, the surprise was located on chromosome 21, where the MX2 gene was associated for the very first time with cancer and should be studied more carefully to understand its role.

The Australian work identified a large area of chromosome 1 rich with genes that might also be associated with melanoma. The relevance of these two works, both with the participation of researchers from IDIBAPS - Hospital Clínic, is reinforced by the fact that the results have been validated both in the European and Australian populations. Thus, the identified genes are relevant to the disease regardless of the population under study. Researchers face a complex puzzle, where environmental factors also play an important role. These data should aid studies aimed at designing new diagnostic and prognostic tools to make possible new treatments as well as to strengthen existing genetic counseling and diagnostic strategies.

For further information:
Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
IDIBAPS Communication
Àlex Argemí (aargemi@clinic.ub.es)
Tel: +34 93 227 57 00
www.idibaps.org

Alex Argemi | EurekAlert!
Further information:
http://www.idibaps.org

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>