Rotavirus is a leading cause of diarrhea among children, both in the developed and developing world. In the United States, the virus causes about 60,000 hospitalizations each year and kills about 40 children below the age of five.
"It is an imperfectly immunizing infection," said Virginia Pitzer, postdoctoral researcher in the Center for Infectious Disease Dynamics and the department of biology, Penn State. "So you can get infected multiple times throughout your life."
Up until the late 1990s, annual rotavirus epidemics in the U.S. followed a predictable pattern. Infections appeared in the southwest and peaked in December or January, then spread to the northeast, where they peaked in March. In recent years epidemics in the southwest have begun later than usual.
Pitzer and her colleagues initially looked at environmental factors such as solar radiation, precipitation and temperature but these could not explain the shifts in outbreaks of new infections. Unlike other viruses that die out and are replenished each year with new strains from outside the United States, rotavirus infections tend to linger in the summer months.
"In general, the pattern of spread of rotavirus outbreaks from the southwest to the northeast is not consistent with any climatic factors," explained Pitzer, whose findings appear today (July 17) in Science. "For instance, temperature tends to be high in the southwest but it also tends to be high in places like Florida, where epidemics occur much later."
Instead, Pitzer and her colleagues looked at human birth rates and the potential link to the timing of rotavirus epidemics. While birth rates are typically high in the southwest and low in the northeast, census data indicates a recent decline in the southwest, particularly in California.
Statistical analysis suggested a negative correlation between birth rates and the timing of the epidemics between 1991 and 2006.
"Each time there was a decline in birth rate, whether from state to state or year to year, infections tended to happen later," explained Pitzer.
A mathematical model using information on the epidemiology of rotavirus and birth rates from states confirmed the statistical correlation and predicted that given the declining birth rate in California, rotavirus epidemics in the state would gradually shift from December to February.
"Since infants often have diarrhea and can be very infectious when they get rotavirus, they are the ones who tend to drive the epidemics," said Pitzer, who is also associated with Fogarty International Center at the National Institutes of Health through the Research and Policy for Infectious Disease Dynamics program. "Thus, you can get outbreaks of rotavirus happening a lot sooner when and where there are more infants being born."
Vaccines introduced in 2006 further confirm Pitzer's model. Since vaccination reduces the number of infants vulnerable to symptomatic infections, the effect is analogous to a decline in birth rate.
"With the effects of vaccination factored in, the model accurately predicted a small decrease in the incidence of severe diarrhea during the 2006-2007 season, and a larger decline and delay during 2007-2008, providing validation for our model," said Pitzer.
Researchers add that high levels of vaccination could further limit the intensity of new epidemics and lead to a period of years with very few cases of severe diarrhea caused by rotavirus.
"The important message here is that vaccination can have a big impact in controlling rotavirus infections," explained Pitzer. "Even those not vaccinated can benefit from those vaccinated because it lowers the overall prevalence of the infection in the population."
Other researchers on the paper include Cecile Viboud, staff scientist; Wladimir J. Alonso, research fellow, and Mark A. Miller, director, division of international epidemiology, all at the Fogarty International Center, National Institutes of Health; Lone Simonsen, visiting professor, George Washington University; Claudia Steiner, research medical officer, U.S. Department of Health and Human Services; Umesh D. Parashar, lead, viral gastroenteritis epidemiology team; Catherine A. Panozzo, surveillance coordinator; and John W. Glasser, epidemiologist, all at the National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention; and Bryan T. Grenfell, professor, Princeton University, formerly at Penn State.
The National Institutes of Health, Bill and Melinda Gates Foundation, and the U.S. Department of Homeland Security supported this work.
Amitabh Avasthi | EurekAlert!
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences