This syndecan-1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyväskylä in Finland.
The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer. According to the researchers, the identification of the syndecan-1 receptor helps in understanding the ways baculovirus interacts with human cells and sheds further light on the mechanisms the virus uses in human cells.
The study also focused on the role of the syndecan-1 receptor in the cell penetration of baculovirus.
The study was published in the prestigious Journal of Virology. The article was featured in the Spotlight section of the journal, which is reserved for especially interesting and distinguished publications.
Used in drugs and vaccines
Baculovirus is an insect-infecting virus, which is largely utilised in biotechnology applications. Baculoviruses are used, for example, in the manufacturing of Glybera, the first gene therapy of the Western world, and in the manufacturing of the cancer vaccines Cervarix and Provenge, and the influenza vaccine Flublok. The technology is approved by the U.S. Food and Drug Administration, FDA, and the European Medicines Agency, EMA.
Baculovirus is not harmful to human cells, and this is why baculoviruses have become subjects of intensive research also with regard to gene therapy. In gene therapy, DNA to correct genetic errors is transported into cells using a variety of methods. Earlier studies have not been able to identify the receptor that recognises the virus, despite the fact that baculovirus has been studied intensively for decades.
The doctoral dissertation of Ms Paula Turkki, MA, on the topic in the field of cell and molecular biology will be publicly examined at the Department of Biological and Environmental Science of the University of Jyväskylä on 25 October 2013.
For further information, please contact:
Professor Kari Airenne, kari.airenne(at)uef.fi, University of Eastern Finland, tel. +358 40 3553131
Early Stage Researcher Emilia Makkonen, MA, emilia.makkonen(at)uef.fi, University of Eastern Finland, tel. +358 40 3553797
University Lecturer Varpu Marjomäki, University of Jyväskylä, tel. +358 40 563 4422, varpu.s.marjomaki(at)jyu.fi
Academy Professor Seppo Ylä-Herttuala, University of Eastern Finland, seppo.ylaherttuala(at)uef.fi, tel. +358 40 3552075
Article in Journal of Virology:
Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ. 6-O- and N-sulfated syndecan-1 promotes baculovirus binding and entry into Mammalian cells. Journal of Virology. 2013. 87(20):11148-11159. http://jvi.asm.org/content/87/20/11148.abstract
Kari Airenne | EurekAlert!
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy