Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Baculovirus-recognizing human cell receptor identified for the first time

30.09.2013
The receptor used by baculovirus to enter and interact with human cells has been identified.

This syndecan-1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyväskylä in Finland.

The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer. According to the researchers, the identification of the syndecan-1 receptor helps in understanding the ways baculovirus interacts with human cells and sheds further light on the mechanisms the virus uses in human cells.

The study also focused on the role of the syndecan-1 receptor in the cell penetration of baculovirus.

The study was published in the prestigious Journal of Virology. The article was featured in the Spotlight section of the journal, which is reserved for especially interesting and distinguished publications.

Used in drugs and vaccines

Baculovirus is an insect-infecting virus, which is largely utilised in biotechnology applications. Baculoviruses are used, for example, in the manufacturing of Glybera, the first gene therapy of the Western world, and in the manufacturing of the cancer vaccines Cervarix and Provenge, and the influenza vaccine Flublok. The technology is approved by the U.S. Food and Drug Administration, FDA, and the European Medicines Agency, EMA.

Baculovirus is not harmful to human cells, and this is why baculoviruses have become subjects of intensive research also with regard to gene therapy. In gene therapy, DNA to correct genetic errors is transported into cells using a variety of methods. Earlier studies have not been able to identify the receptor that recognises the virus, despite the fact that baculovirus has been studied intensively for decades.

The doctoral dissertation of Ms Paula Turkki, MA, on the topic in the field of cell and molecular biology will be publicly examined at the Department of Biological and Environmental Science of the University of Jyväskylä on 25 October 2013.

For further information, please contact:

Professor Kari Airenne, kari.airenne(at)uef.fi, University of Eastern Finland, tel. +358 40 3553131

Early Stage Researcher Emilia Makkonen, MA, emilia.makkonen(at)uef.fi, University of Eastern Finland, tel. +358 40 3553797

University Lecturer Varpu Marjomäki, University of Jyväskylä, tel. +358 40 563 4422, varpu.s.marjomaki(at)jyu.fi

Academy Professor Seppo Ylä-Herttuala, University of Eastern Finland, seppo.ylaherttuala(at)uef.fi, tel. +358 40 3552075

Article in Journal of Virology:

Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ. 6-O- and N-sulfated syndecan-1 promotes baculovirus binding and entry into Mammalian cells. Journal of Virology. 2013. 87(20):11148-11159. http://jvi.asm.org/content/87/20/11148.abstract

Kari Airenne | EurekAlert!
Further information:
http://www.uef.fi

Further reports about: Baculovirus-recognizing Virology gene therapy genetic error human cell

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>