Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Arsenic for better drugs and cleaner crops

25.06.2012
Research carried out at the University of Gothenburg may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.

Even though arsenic is toxic for many organs in the human body, it is used in the treatment of some forms of cancer, and it is an active component of drugs against parasitic diseases.

Healing arsenic

Arsenic is used in therapeutic medicine, but we know relatively little about the mechanisms by which cells develop resistance to arsenic, which may lead to a lower therapeutic effect.

Proteins control cellular processes

Scientist Doryaneh Ahmadpour at the Department of Chemistry and Molecular Biology, University of Gothenburg, has carried out experiments with common baker’s yeast, in order to find out how inflow and outflow take place in cells.

“The knowledge we obtain from determining these mechanisms in yeast can be subsequently used in the long term to produce more effective drugs containing arsenic. A membrane protein known as Fps1 is particularly interesting. This protein transports the trivalent form of arsenic (arsenite) into and out from the cell,” says Doryaneh Ahmadpour.

She has worked with scientist Michael Thorsen to show how the Fps1 protein is regulated and how the inflow into the cell of arsenic is influenced by another protein, Hog1.

The results suggest that a reduction in the activity of Hog1 is an effective way of increasing the ability of the cell to absorb arsenic. This may make the cell more sensitive to arsenic and thus give more effective treatment.

Resistance to arsenic can be increased in a similar manner, by increasing the activity of Hog1, which reduces the inflow of arsenic into the cells.

“We have shown also that a protein known as Slt2 regulates the outflow of arsenic from the cell, and increases the resistance of the cell to arsenic. It is possible, in the same way, to regulate the cellular resistance against arsenic by controlling the activity of Slt2.”

Arsenic as a problem

Arsenic is a toxic metalloid that is naturally found in earth crust. It can be leached out by water or spread by industrial activity.

Arsenic is a global problem due to the increasing contamination of water, soil and crops, not only in the industrialized world but also in developing countries.

“High levels of arsenic in groundwater can lead to humans being exposed to toxic levels in food and water. This affects mainly people in regions in which the crops are watered with arsenic-contaminated water, leading to arsenic being stored in the plants.”

Resistant crops

Increased knowledge about arsenic can be used to produce plants with a high absorption, and these can be used to clean contaminated land. The knowledge can also be used to produce food crops, known as “safe crops”, with a limited absorption and storage of arsenic.

The thesis has been successfully defended.

For more information, please contact: Doryaneh Ahmadpour, Department of Chemistry and Molecular Biology, University of Gothenburg
Mobile: +46 73 766 6028
E-mail: doryaneh.ahmadpour@cmb.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://hdl.handle.net/2077/28374

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>