The study was presented today at the annual meeting of ESHRE by Dr Ulrik Schiøler Kesmodel from the Fertility Clinic of Aarhus University Hospital in Denmark. Results showed that the consumption of five or more cups of coffee a day reduced the clinical pregnancy rate by 50% and the live birth rate by 40%.
"Although we were not surprised that coffee consumption appears to affect pregnancy rates in IVF, we were surprised at the magnitude of the effect," said Dr Kesmodel.
The link between caffeine and fertility has been studied on occasions in the past, with conflicting results. Some studies have found an increased incidence of spontaneous abortion in coffee drinkers, but other studies have not. Similarly, a Cochrane review from 2009 found there was insufficient evidence to confirm or deny the effect of "caffeine avoidance" on pregnancy outcome. However, one much cited study from 2004 showed that time-to-pregnancy was significantly extended in women when coffee or tea intake was more than six cups per day or when the male partner consumed more than 20 alcohol units per week.(1)
This latest Danish study, which was performed in a large public IVF clinic, was a prospective follow-up of 3959 women having IVF or ICSI as fertility treatment. Information on coffee consumption was gathered at the beginning of treatment (and at the start of each subsequent cycle). The statistical analysis controlled for such confounding variables as female age, female smoking habits and alcohol consumption, cause of infertility, female body mass index, ovarian stimulation, and number of embryos retrieved.
The analysis showed that the "relative risk" of pregnancy was reduced by 50% in those women who reported drinking five or more cups of coffee per day at the start of treatment - and the chance of live birth was reduced by 40% (though this trend was not quite statistically significant). No effect was observed when the patients reported coffee consumption of less than five cups.
In their conclusion, the authors compared the adverse effect of five cups of coffee "to the detrimental effect of smoking". Several recent studies and reviews have indicated that tobacco smoking has an adverse effect in IVF on the number of oocytes retrieved, and rates of fertilisation, implantation, pregnancy and live birth.(2)
Commenting on his results, Dr Kesmodel proposed that in a study of greater numbers the statistical effect of coffee on IVF delivery results would have most likely been significant, and comparable to the effects seen on pregnancy rate.
"There is limited evidence about coffee in the literature," said Dr Kesmodel, "so we would not wish to worry IVF patients unnecessarily. But it does seem reasonable, based on our results and the evidence we have about coffee consumption during pregnancy, that women should not drink more than five cups of coffee a day when having IVF."The fact that we found no harmful effects of coffee at lower levels of intake is well in line with previous studies on time-to-pregnancy and miscarriage, which also suggest that, if coffee does have a clinically relevant effect, it is likely to be upwards from a level of four-to-six cups a day."
From abstract no: O-202 Tuesday 3 July 2012, 17.45 hrs EEST
Does coffee consumption reduce the chance of pregnancy and live birth in IVF?
Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
The 28th Annual Meeting of ESHRE, the world's largest event in reproductive science and medicine, is taking place in Istanbul from 1-4 July 2012
Christine Bauquis | EurekAlert!
New photocatalyst speeds up the conversion of carbon dioxide into chemical resources
29.05.2017 | DGIST (Daegu Gyeongbuk Institute of Science and Technology)
Copper hydroxide nanoparticles provide protection against toxic oxygen radicals in cigarette smoke
29.05.2017 | Johannes Gutenberg-Universität Mainz
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Life Sciences
29.05.2017 | Physics and Astronomy
29.05.2017 | Statistics