During the past twelve months Genedata Screener has provided computational support throughout a complete screening cycle at Chugai. Beginning with assay optimization and followed by primary and validation screening phases, Screener has enhanced Chugai’s search for active compounds with more robust measures for biological effects within the screening cascade.
Genedata’s computational scientists in Japan, based in Tokyo, have integrated Genedata Screener with research infrastructure at Chugai. It has been connected to Chugai’s screening platforms and result databases, providing data quality assurance and automating the analysis process from the plate readers all the way to the corporate databases.
Chugai’s screening experts use the AssayAnalyzer module to gain an overview of data quality for entire screening campaigns. Genedata’s Condoseo module is used to estimate the potency of compounds screened at multiple concentrations in the validation screening phase.
Actions speak louder than words
Genedata’s collaboration with Chugai began with a case study performed on data generated at Chugai’s research facilities in Kamkura, near Tokyo. Genedata analyzed a complete data set composed of primary and validation screening data, and presented the results to Chugai’s scientists.
The case study demonstrated the speed and efficiency of Genedata’s computational approach to screening analysis. “Data visualization and data quality assurance were key drivers behind choosing Genedata’s solution”, explained Hiroki Takaya, Group Manager, Pharmaceutical Technology Department, Chugai Pharmaceutical Co., Ltd.
This is Genedata Screener’s first collaboration in Japan. “We are strengthening our customer base internationally and our success with Chugai validates our approach to achieving close collaboration with customers on a global scale”, said Dr. Stephan Heyse, Head of Genedata Screener, Genedata AG.
tobe freeman | alfa
PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems
11.12.2017 | Fraunhofer-Institut für Zuverlässigkeit und Mikrointegration IZM
Rules for superconductivity mirrored in 'excitonic insulator'
08.12.2017 | Rice University
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Earth Sciences
11.12.2017 | Information Technology