Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CSIRO based drug effective against bird flu

20.02.2004



Drugs based on CSIRO’s research into the influenza virus have been shown to be effective, in laboratory tests, against a sample of an H5N1 influenza virus currently infecting chickens in Asia.

CSIRO Health Sciences and Nutrition scientist, Dr Jenny McKimm-Breschkin, has tested the ability of the flu drug Relenza™ to inhibit the virus, known as H5N1 strain, which has killed millions of chickens in Asia and has been responsible for several human deaths this year.

The tests, used to monitor virus sensitivity to drugs, have shown that the drug Relenza™ is as effective, in laboratory experiments, against this bird flu as it is against other strains of flu that affect humans.



"There is a direct correlation between enzyme sensitivity as measured by these laboratory tests and the ability of the drug to prevent the virus from multiplying," said Dr McKimm-Breschkin.

In 1999, the world’s first drug effective against all strains of influenza was released onto the world market. Relenza™ was designed based on CSIRO’s discovery that there was a small section on the surface of the influenza virus that doesn’t change between strains of flu. Designing a drug to inhibit the action of this part of the virus meant it would be very difficult for the virus to mutate to avoid binding the drug. No drug resistance has been seen globally in any previously healthy patient treated with Relenza™.

Subsequently a second drug, Tamiflu™, was developed based on CSIRO research. Its manufacturers claim that pre-clinical trials provide reassurance that it could be effective against bird flu.

The Asian bird flu has not been shown to be passed from human to human. All those who have died from this disease have caught it directly from infected birds. The current strategy for preventing this virus from spreading further and endangering more humans has been to cull millions of chickens in Asian farms and markets.

"In the event that the disease does mutate into a form which can be passed from human to human it is important to know that we already have a treatment available," said Dr McKimm-Breschkin. "The fact that our experiments show that in the laboratory this Australian designed drug is effective against bird flu again shows just how important a discovery this was."

In order to establish that Relenza™ is effective in humans infected with bird flu, clinical data from humans will be needed.

The same techniques used in the development of Relenza™ are being employed by CSIRO to fight other diseases such as cancer, psoriasis and inflammatory diseases like rheumatoid arthritis.

It should be noted that CSIRO receives a royalty income from sales of Relenza™. The assay results reported here have been conducted independently of the manufacturers of Relenza™.

More information:

Mr Warrick Glynn, CSIRO Health Sciences and Nutrition,
PH: 61 3 9662 7344, Mobile: 0408 117 846
Email: Warrick.Glynn@csiro.au

Rosie Schmedding | CSIRO
Further information:
http://www.csiro.au/index.asp?type=mediaRelease&id=PrBirdFlu5

More articles from Agricultural and Forestry Science:

nachricht Researchers discover a new link to fight billion-dollar threat to soybean production
14.02.2017 | University of Missouri-Columbia

nachricht Important to maintain a diversity of habitats in the sea
14.02.2017 | University of Gothenburg

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>