Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New optimized coatings for implants reduce risk of infection

19.12.2013
Researchers at Aalto University have developed a method of selection of new surface treatment processes for orthopaedic and dental implants to reduce the risk of infection.

Implants are commonly made from metals such as titanium alloys. These materials are being made porous during processing used to prepare them for medical use.


Computer tomography of porous titanium coating made on the implant surface


Model for inverse humeral (shoulder) implant

Whereas this is important to ensure good contact between the implant and the bone, this also allows dangerous bacteria to adhere and grow both on the surface as well as inside leading to increased risk of infection.

“Our work has focused on developing an analysis of surface treatments for commercial implants which reduces risk of infection,” said Professor Michael Gasik at Aalto University. “What we wanted to do is find a way to avoid the formation of any undesirable products during the processing of the implant.”

“At the same time we needed to make sure that the bio-mechanical properties of the implant would remain intact and, even more, become better.”

A thin coating of a biomaterial called Hydroxyapatite (HAP) or bioactive glass (BAG) is typically applied to orthopaedic and other implants to alter the surface properties.

Such coatings improve the body ability to recognize a foreign object in a more friendly way and promote implant integration into surrounding tissues. During the heat treatment process, excessive stresses can cause premature cracking and removal of the coating layer. This can lead to the development of unsuitable compounds and increase the risk of infection.

“Normally, implants require a certain level of porosity and elasticity to function properly,” added Professor Gasik. “The challenge for us was to ensure full functionality of the implant while maintaining sufficient density of the coating during the heat treatment process.” “We have proven that by adding a certain amount of another compound called beta-tricalcium phosphate (ß-TCP) such stresses are reduced and therefore preserves the biomaterial coating better.” Thus minimizing the risk of coating destruction and bacterial adhesion, and improving cell proliferation, allows the implant surface to achieve its function in an optimal way.

This research is significant in the battle against the spread of drug resistant bacteria. An estimated 10-15% of post-implant complications are caused by bacterial infections. Post-operative diseases are becoming more challenging and developing new treatments that are resistant to infection are crucial. In response to this research, Aalto University and partner manufacturers have already started developing new experimental devices for advanced testing of biomaterials at the conditions most close to life. Besides proving developed technology, it will allow high-throughput screening of the biomaterials with substantially better properties.

The research was conducted at Aalto University and supported by Tekes, the Finnish national innovation agency, and by the EU FP6 project “Meddelcoat”.

More information:
Professor Michael Gasik
Aalto University, School of Chemical Technology
michael.gasik@aalto.fi
Tel. +358 50 5609511
The articles:
Michael Gasik, Anu Keski-Honkola, Yevgen Bilotsky, Michael Friman: DEVELOPMENT AND OPTIMIZATION OF HYDROXYAPATITE - ß-TCP FUNCTIONALLY GRADATED BIOMATERIAL. Journal of the Mechanical Behavior of Biomedical Materials (2013), dx.doi.org/10.1016/j.jmbbm.2013.11.017

Michael Gasik, Lieve Van Mellaert, Dorothée Pierron, Annabel Braem, Dorien Hofmans, Evelien De Waelheyns, Jozef Anné, Marie-Françoise Harmand, Jozef Vleugels. REDUCTION OF BIOFILM INFECTION RISKS AND PROMOTION OF OSTEOINTEGRATION FOR OPTIMIZED SURFACES OF TITANIUM IMPLANTS. Advanced Healthcare Materials, 1, No. 1 (2012), 117–127.

Aalto University, Finland is a new multidisciplinary science and art community in the fields of science, economics, and art and design. The University is founded on Finnish strengths, and its goal is to develop as a unique entity to become one of the world's top universities. Aalto University's cornerstones are its strengths in education and research. At the new University, there are 20,000 basic degree and graduate students as well as a staff of 5,000 of which 370 are professors.

Jenni Jeskanen
Communications
Aalto University
+358 50 372 7062

Jenni Jeskanen | Aalto University
Further information:
http://www.aalto.fi

More articles from Materials Sciences:

nachricht New design improves performance of flexible wearable electronics
23.06.2017 | North Carolina State University

nachricht Plant inspiration could lead to flexible electronics
22.06.2017 | American Chemical Society

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>