High Estrogen Levels, Diabetes Together May Increase Dementia Risk 14-Fold in Older Women
Blood estrogens were measured in women free of dementia aged 65 or older. After a four-year follow-up, 543 women who did not have dementia were compared with 132 women who had dementia. Scientists looked at a number of risk factors for dementia, including diabetes, high blood pressure, abnormal blood clotting and other heart health risk factors.
The study found that the risk of dementia more than doubled for women who had high estrogen levels after accounting for other dementia risk factors. For those who had high estrogen levels and diabetes, the risk for dementia increased dramatically, by 14 times.
Estrogen levels were about 70 percent higher in women with diabetes who also had dementia compared to those without dementia. No other heart health risk factors raised the dementia risk.
“These results are surprising, given the expected brain protective effects of estrogen-based therapy,” said study author Pierre-Yves Scarabin, MD, with the French National Institute of Health and Medical Research (INSERM) in Villejuif, France. “However, more and more evidence suggests an association between high estradiol levels and dementia in women who have undergone menopause. Considering the expected increase in the number of elderly people with diabetes and dementia, more research on this topic should be urgently conducted.”
The research was supported by INSERM, the Victor Segalen-Bordeaux II University, Sanofi-Aventis, Foundation for Medical Research, National Health Fund for Employees, Directorate General of Health, MGEN, Institute of Longevity, Regional Councils of Aquitaine and Bourgogne, Foundation of France, and the National Agency of Research.
To learn more about dementia, please visit www/aan.com/patients.
The American Academy of Neurology, an association of more than 27,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com
Media Contact
More Information:
http://www.aan.comAll latest news from the category: Studies and Analyses
innovations-report maintains a wealth of in-depth studies and analyses from a variety of subject areas including business and finance, medicine and pharmacology, ecology and the environment, energy, communications and media, transportation, work, family and leisure.
Newest articles
Hubble Views the Dawn of a Sun-like Star
Looking like a glittering cosmic geode, a trio of dazzling stars blaze from the hollowed-out cavity of a reflection nebula in this new image from NASA’s Hubble Space Telescope. The…
Engineering a new color palette for single-molecule imaging
A new paper published in Nature Nanotechnology outlines a way to create dozens of new “colors” to multiplex single-molecule measurements. Researchers often study biomolecules such as proteins or amino acids…
Using solar energy to generate heat at high temperatures
The production of cement, metals and many chemical commodities requires extremely high temperatures of over a thousand degrees Celsius. At present, this heat is usually obtained by combusting fossil fuels:…
