High-tech in radiology: destroying tumor tissue with microbubbles

Durchführung des neuen Histotripsie-Verfahrens durch Radiologe und Klinikdirektor Prof. Dr. med. Maciej Pech
Christian Morawe / Universitätsmedizin Magdeburg

In the Magdeburg University Clinic for Radiology, the first patient in Europe has been treated with a new type of liver tumor therapy as a part of a clinical study.

Histotripsy is the name of the innovative new procedure from the US, which has now been tested on a patient at the University Hospital for Radiology and Nuclear Medicine Magdeburg as part of the so-called #HOPE4LIVER study. This makes Magdeburg University Hospital the first site in all of Europe to treat a patient with liver tumors within this Phase I clinical trial. Previously, in the US, the first patient was enrolled in this pivotal trial, in which initially only a few patients were participating. In the first step, the aim is to investigate the safety and efficacy of the novel histotripsy method. This is a form of focused ultrasound that mechanically destroys primary and metastatic liver tumors without the need for skin incisions or needles placed in the patient’s body.

Clinic director Prof. Maciej Pech, MD, performed the novel procedure in Magdeburg. Histotripsy uses the power of induced microbubbles in the cell to destroy the target tissue, which avoids the ionizing energy of radiation, heat damage from thermal modalities and incisions or needles from traditional interventional treatments. The radiologist said after the treatment, “Our first treatment in the #HOPE4LIVER trial was successful in destroying the targeted tumor and the patient was doing well both during and after the treatment. We will continue to treat the patient and look forward to enrolling additional patients for whom histotripsy therapy is appropriate. The ability to destroy tumors non-invasively with histotripsy could be a huge advantage for many patients, as it is very gentle to use, which would make outpatient therapy possible.”

Only 20 to 30 percent of patients with multiple liver tumors are primary candidates for surgical resection when anatomic limitations, poor underlying liver function, or general health problems limit the success of surgery. Histotripsy has the potential to be able to offer these patients advantages in prolonged treatment due to its non-invasive, non-thermal and non-ionizing tumor destruction.

In addition to the University Medical Center Magdeburg, Braunschweig is also among the other study sites in Germany. The Company intends to establish up to seven study sites in selected European countries. Each site will be led by experienced clinical investigators and multidisciplinary liver specialists. Patients eligible for the European #HOPE4LIVER study will undergo non-invasive histotripsy to destroy up to three primary or metastatic liver tumors in a single session. If the #HOPE4LIVER trials are successful, both in the U.S. and Europe, the company plans to seek regulatory approval for the technology. In the long term, the company said it is also considering expanding its use to other organs to be treated.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Maciej Pech, Clinic director of University Hospital for Radiology and Nuclear Medicine Magdeburg, e-mail: Maciej.Pech@med.ovgu.de, phone: +49 391 67 13030

http://www.med.uni-magdeburg.de/

Media Contact

Friederike Süssig-Jeschor Pressestelle
Universitätsmedizin Magdeburg

All latest news from the category: Medical Engineering

The development of medical equipment, products and technical procedures is characterized by high research and development costs in a variety of fields related to the study of human medicine.

innovations-report provides informative and stimulating reports and articles on topics ranging from imaging processes, cell and tissue techniques, optical techniques, implants, orthopedic aids, clinical and medical office equipment, dialysis systems and x-ray/radiation monitoring devices to endoscopy, ultrasound, surgical techniques, and dental materials.

Back to home

Comments (0)

Write a comment

Newest articles

Mapping the heart to prevent damage caused by a heart attack

Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a…

Cannabis use tied to increased risk of severe COVID-19

Similar to smokers, cannabis users nearly twice as likely to need hospitalization, intensive care when infected with the virus. As the deadly disease that came to be known as COVID-19…

A glass that builds and heals itself

Researchers from Tel Aviv University have for the first time created a transparent, self-repairing adhesive glass that forms spontaneously when it comes in contact with water. An international discovery published…

Partners & Sponsors