Testosterone is an ally of macrophages in the battle against adrenal cancers
Why are cancers of the adrenal glands1 more common among women? Why are prognoses worse for them? A team of scientists led by a CNRS researcher answers these questions in an article published on 14 October 2022 in Science Advances. They demonstrate that, in male mice, there is greater recruitment of immune cells known as macrophages, which can eliminate tumour cells.
Hence, aggressive tumour progression is scarcely seen in male mice; while in female miles, macrophages do not slow the growth of tumours, which eventually metastasize. Through molecular analyses, the team determined that recruitment of tumour-fighting macrophages depends on testosterone. After simple administration of the hormone to females, macrophages able to eradicate tumour cells were rallied to battle.
On the basis of these findings, the scientists conducted another study using data on humans, which revealed the same difference in macrophage recruitment rates between men and women with adrenal cancers. This discovery suggests the potential of hormonal stimulation as a treatment for this type of cancer, whose five-year survival rate is less than 30%.
1Le corps humain compte deux glandes surrénales, chacune située au-dessus d’un rein. Elles secrètent des hormones telles que l’adrénaline (participant, entres autres, au contrôle de la tension artérielle, de la fréquence cardiaque ou de la transpiration), des corticoïdes (impliqués dans le contrôle de la tension artérielle, des taux de sel et de potassium dans l’organisme et du métabolisme des sucres et des graisses), et des androgènes.
Journal: Science Advances
Article Title: Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development
Article Publication Date: 14-Oct-2022
All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Being prepared for storm surges on the Baltic Sea coast
Kiel researchers evaluate the future protection potential of dikes and show flooding scenarios for the German Baltic Sea coast until 2100. The record storm surge in October 2023 caused severe…
Protected droplets a new transport route for medicines
Microgels form a thin protective shell around a droplet until the temperature rises above 32 degrees. Then the microgels shrink and the droplet dissolves in the surrounding liquid. A study…
Insilico Medicine showcases latest AI drug discovery platform breakthroughs
Insilico Medicine (“Insilico”), an artificial intelligence (AI)-driven, clinical stage biotechnology company and leader in AI drug discovery platform technology, is hosting three webinars unveiling its latest technology breakthroughs Nov. 28-30,…