Study elucidates the mechanism underlying “Cocktail Effects” of endocrine disrupting chemicals

Cocktails of endocrine disrupting chemicals affect the function of human sperm, which might interfere with the fertilization process Image: R. Pascal, Caesar, Bonn

Endocrine disrupting chemicals, omnipresent in food, plastics, textiles, and cosmetics, might be involved in fertility disorders, which are on the rise in the Western world. The chemicals impair the function of human sperm. They mimic the action of female hormones that control the swimming behavior of the sperm in the oviduct. Thereby, the chemicals could interfere with the fertilization process.

Scientists around Prof. Timo Strünker from the Centre of Reproductive Medicine and Andrology (CeRA, University of Münster, Germany) and Prof. Niels Erik Skakkebæk from the Rigshospitalet, Copenhagen (Denmark) have now taken another, closer look at the chemical´s action in sperm; in particular, at the so-called cocktail effect.

In our daily life, we incorporate a complex mixture of various endocrine disruptors – each individual chemical, however, only in a very low, rather ineffective concentration. Despite the miniscule concentrations of the individual components, cocktails of endocrine disruptors, such as those found in blood, have a pronounced action in sperm.

“The results of our new study can be easily summarized,” says Dr. Christoph Brenker from the CeRA, head of the study: “If the chemicals teams up in cocktails, their individual actions do not simply add up, but amplify each other.

In pharmacology, this phenomenon is called “synergism”: one plus one does not make two, but three! The researchers found that also the female hormones have a synergistic action in sperm. “The endocrine disruptors just imitate the female hormones – including their synergistic interaction,” said Brenker.

Whether the use of endocrine disrupting chemicals should be further restricted is a much debated question. The new results are important for assessing their toxic action: so far, “safety limits” are determined only for each chemical individually.

Considering that in cocktails, the actions of individual chemicals become amplified, such an isolated risk assessment is prone to underestimate the risk potential of endocrine disrupters. In fact, synergistic actions of endocrine disruptors have also been observed in other cells and tissues.

Media contact:

Dr. Thomas Bauer
Telefon: 0251 83-58937
E-Mail: thbauer@uni-muenster.de

Brenker C. et al.: Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals. Human Reproduction 2018 Sep 5; doi: 10.1093/humrep/dey275 (Epub ahead of print)

Media Contact

Dr. Thomas Bauer idw - Informationsdienst Wissenschaft

Weitere Informationen:

https://www.uni-muenster.de/

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

High-thermoresistant biopolyimides become water-soluble like starch

This is the first report for the syntheses of water-soluble polyimides which are Interestingly derived from bio-based resources, showing high transparency, tunable mechanical strength and the highest thermoresistance in water-soluble…

Land management in forest and grasslands

How much can we intensify? A first assessment of the effects of land management on the links between biodiversity, ecosystem functions and ecosystem services. Ecosystem services are crucial for human…

A molecular break for root growth

The dynamic change in root growth of plants plays an important role in their adjustment to soil conditions. Depending on the location, nutrients or moisture can be found in higher…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close