Linheng Li Lab documents the development of cancer stem cells

The paper, “PTEN-deficient intestinal stem cells initiate intestinal polyposis” was posted to the Nature Genetics Web site on January 21.

The theory that cancer stem cells initiate and drive cancer cell growth has been gaining popularity in both clinical and basic research. Recent studies have identified cancer stem cells and shown that they may cause tumors when transplanted into a secondary host. Until now, however, little was known about the process by which mutations in a stem cell result in primary tumor initiation.

The Li Lab team studied the intestinal system in mice in which one of the human tumor suppressor genes, PTEN, had been deleted. They found that the PTEN/Akt pathway likely regulates stem cell activation by helping control nuclear localization of beta-catenin, the Wnt pathway effector, through phosphorylation of beta-catenin — including Serine552.

“We found that a loss of PTEN in intestinal epithelial cells accompanied by a loss of PTEN in stromal cells can lead to changes that may increase the number of stem cells and change their position or location,” said Dr. Li. “These changes result in crypt fission and budding and can lead to intestinal polyposis and uncontrolled tumor growth.”

“All of us were very excited to be part of these efforts to reveal basic features of cancer stem cells,” said Dr. He. “What we learned — that cancer stem cells are a rare population in the tumor mass; that they are slow cycling but more active than normal stem cells; and that cancer stem cells and stromal insertions initiate the process of primary tumorigenesis — will be influential in our future work.”

“Findings from the Li Lab create opportunities to further characterize cancer stem cells and to obtain their molecular signature — providing important insight into targeting these cells,” said Robb Krumlauf, Ph.D., Scientific Director. “This is a fascinating new area of cancer research, and Linheng Li and his colleagues will continue to make important contributions.”

Media Contact

Marie Jennings EurekAlert!

Weitere Informationen:

http://www.stowers-institute.org

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Flash graphene rocks strategy for plastic waste

Rice University lab detours potential environmental hazard into useful material. Plastic waste comes back in black as pristine graphene, thanks to ACDC. That’s what Rice University scientists call the process…

Towards next-generation molecule-based magnets

Magnets are to be found everywhere in our daily lives, whether in satellites, telephones or on fridge doors. However, they are made up of heavy inorganic materials whose component elements…

Order in the disorder …

… density fluctuations in amorphous silicon discovered Silicon does not have to be crystalline, but can also be produced as an amorphous thin film. In such amorphous films, the atomic…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close