DNA Origami nanoturbine sets new horizon for nanomotors

DNA Origami nanoturbine sets new horizon for nanomotors
Image Cees Dekker Lab / SciXel

Nanoturbines: the heart of advancements

Flow-driven turbines lie at the heart of many revolutionary machines that have shaped our societies, from windmills to airplanes. Even life itself depends critically on turbines for fundamental processes, such as the FoF1-ATP synthase that produces fuels for biological cells and the bacterial flagella motor that propels bacteria. “Our nanoturbine has a 25-nanometer diameter rotor made from DNA material with blades configured in a right-handed or left-handed sense to control the direction of rotation. To operate, this structure is docked in a strong water flow, controlled by an electric field or salt concentration difference, from a nanopore, a tiny opening, in a thin membrane. We used our turbine to drive a rigid rod up to 20 revolutions per second”, says Shi.

A fascinating revelation

One of the most intriguing discoveries of this research is the unique nature of the DNA origami nano-turbine’s rotation. Its behaviour is influenced by ion concentration, allowing the same turbine to spin either clockwise or anticlockwise, depending on the concentration of Na+ ions in the solution. This unique feature, exclusive to the nanoscale realm, results from the intricate interplay between ions, water, and DNA. These findings, rigorously supported by extensive molecular dynamics simulations by the group of Aleksei Aksimentiev at University of Illinois and theoretical modelling by Ramin Golestanian at MPI Göttingen, hold the promise of expanding the horizons of nanotechnology, and offer numerous applications. For example, in the future, we might be able to use DNA-origami to make nanomachines that can deliver drugs into the human body, to specific types of cells.

DNA Origami nanoturbine sets new horizon for nanomotorsDNA Origami nanoturbine sets new horizon for nanomotors: Image Cees Dekker Lab / SciXel


DNA origami

Cees Dekker, who supervised the research, sheds light on their methodology: “Together with our collaborators at Hendrik Dietz’s lab from the Technical University of Munich, we used insights from our previous work on DNA rotary motors to now create a turbine with full control over its design and operation”. The ‘DNA origami’ technique uses the specific interactions between complementary DNA base pairs to build dynamic 3D nano-objects. This design allows the direction of rotation of the turbine in our nanopores to be controlled through the handedness of the blades and allows straightforward integration of the turbine to other nanomachines.

A new step towards active transmembrane nanomachines

This research achievement follows last year’s introduction of the DNA active nanorotor, a self-configuring device capable of transforming energy from electrical or salt gradients into practical mechanical work. Read more: TU Delft researchers create flow-driven rotors at the nanoscale

Reflecting on the remarkable journey, Xin Shi underscores the significance of their progress: “We’ve unveiled the fundamental principles behind propelling a nanoscale rotor using water and salt in nanopores. This year’s breakthrough, driven by rational design, marks the next phase of our journey. The foundational principles from our previous paper, combined with the innovations in this one, set the stage for the future of biomimetic transmembrane machines, with the potential to harness energy from salt gradients, a vital energy source employed by biological motors.”

Journal: Nature Nanotechnology
DOI: 10.1038/s41565-023-01527-8
Method of Research: Imaging analysis
Subject of Research: Cells
Article Title: A DNA turbine powered by a transmembrane potential across a nanopore
Article Publication Date: 26-Oct-2023

Media Contact

Fien Bosman
Delft University of Technology


Media Contact

Fien Bosman
Delft University of Technology

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Spinning sustainable and functional fiber materials

The German Institutes of Textile and Fiber Research Denkendorf (DITF) have modernized and significantly expanded their melt spinning pilot plant with support from the State of Baden-Württemberg. The new facility…

Network of quantum sensors boosts precision

Quantum sensor technology promises even more precise measurements of physical quantities. A team led by Christian Roos at the University of Innsbruck has now compared the signals of up to…

Astronomers reveal a new link between water and planet formation

Researchers have found water vapour in the disc around a young star exactly where planets may be forming. Water is a key ingredient for life on Earth, and is also…

Partners & Sponsors