Treatment of Obesity
The invention consists in a method of inducing lipid oxidation or increasing insulin sensitivity through the administration of a ligand which binds to the IL-6 receptor and signals via a gp130/LIF (leukemia inhibitory factor) receptor heterodimer. The chimeric ligand has the potential to be a highly effective therapy for obesity. Through this new methodology for increasing lipid oxidation there is no induction of an inflammatory state, no high concentrations of cytokine need to be used and no autoantibodies will be generated. The invention is particularly useful in treating subjects suffering from symptoms caused by obesity, excessive appetite and overweight, as well as obesity-associated metabolic disorders such as hypertension, osteoarthritis, type II diabetes, increased blood pressure, stroke and heart disease.
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