Stimulating neurogenesis of adult neural stem cells by activating death receptor CD95
Optimizing the survival and differentiation of neural stem cells is one of the major goals in stem cell biology today. The present invention achieves this goal by the discovery that the ligand for CD95 (APO-1/Fas), namely, CD95L, induces neuronal differentiation in vitro and in vivo and use of CD95L compositions to effect differentiation. The present invention demon-strates that activation of CD95 can promote neurogenesis in neural stem cells (NSCs) in areas of neuronal damage or injury.
Further Information: PDF
DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Microscopic basis of a new form of quantum magnetism
Not all magnets are the same. When we think of magnetism, we often think of magnets that stick to a refrigerator’s door. For these types of magnets, the electronic interactions…
An epigenome editing toolkit to dissect the mechanisms of gene regulation
A study from the Hackett group at EMBL Rome led to the development of a powerful epigenetic editing technology, which unlocks the ability to precisely program chromatin modifications. Understanding how…
NASA selects UF mission to better track the Earth’s water and ice
NASA has selected a team of University of Florida aerospace engineers to pursue a groundbreaking $12 million mission aimed at improving the way we track changes in Earth’s structures, such…
