This week in the Proceedings of the National Academy of Sciences USA a research team from the University Medical Center Hamburg-Eppendorf (UKE) reports that there is a critical period in infant and young brains, when a specific gene needs to be activated to make complex learning in adulthood at all possible. The findings may have implications for child education and treatment of psychiatric disorders in which brain development was disturbed.
During early postnatal development, primary sensory regions of the brain undergo periods of heightened plasticity (critical period), which sculpt neural networks and lay the foundation for adult sensory perception.
“If such critical periods exists for complex behavior has long been debated” says Dietmar Kuhl, director of the Institute for Molecular and Cellular Cognition at the Center for Molecular Neurobiology (ZMNH) of the UKE.
“Our study shows that this is indeed the case. During a critical period in the development of the brain, the gene Arc/Arg3.1 is activated. It is responsible for establishing neuronal networks, which are required later for complex learning.”
In previous work, Dietmar Kuhl and his team identified Arc/Arg3.1 and demonstrated its vital role in storing long lasting memories in adults. Animals lacking this gene exhibit Alzheimer-like loss of memory although they are otherwise perfectly healthy.
In their new study, the Hamburg team discovered that Arc/Arg3.1 is also activated in the brains of infant and young mice. “These findings puzzled us, because mice of this age are not yet capable of forming long term memories”, explains Ora Ohana, who codirected this study with Dietmar Kuhl.
“We now could demonstrate that mice, which expressed the Arc/Arg3.1 gene during infancy and childhood, were capable of faster and more complex learning compared to mice, which lacked the gene during this critical period.”
According to the scientists, the new findings will pave the way to understand how regulation of Arc/Arg3.1 by genetic, environmental factors, as well as experience during childhood can determine adult cognitive capacity.
“This research will ultimately help to provide optimal environments for child-raising and better treatments for neuropsychiatric conditions in which brain development was disturbed”, says Xiaoyan Gao, one of the authors of the study.
The Medical Center Hamburg-Eppendorf (UKE)
Since its foundation in 1889, the Medical Center Hamburg-Eppendorf (UKE) has been one of the leading clinics in Europe. With about 11,000 employees, the UKE is one of the largest employer in the Free and Hanseatic City of Hamburg.
Together with its University Heart Center Hamburg and the Martini Clinic, the UKE has more than 1,730 beds and treats about 472,000 patients a year. The emphasis in UKE’s research are the neurosciences, cardio-vascular research, care research, oncology, as well as infections and inflammations. Other potential areas of the UKE are molecular imaging and skeletal biology research.
The UKE educates about 3,400 medical specialists and dentists.
Knowledge, Research, Healing through Shared Competence: The UKE | www.uke.de
Prof. Dr. Dietmar Kuhl
Institut für Molekulare und Zelluläre Kognition
Universitätsklinikum Hamburg-Eppendorf (UKE)
Telefon: 040 7410-56277
Gao et al., Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks, Pro-ceedings of the National Academy of Sciences USA (PNAS)
Saskia Lemm | idw - Informationsdienst Wissenschaft
How Humans and Machines Navigate Complex Situations
19.11.2018 | Max-Planck-Institut für Bildungsforschung
The Maturation Pattern of the Hippocampus Drives Human Memory Deve
23.07.2018 | Max-Planck-Institut für Bildungsforschung
A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)
It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.
The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...
Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.
Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...
A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.
The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...
Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).
Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...
02.10.2019 | Event News
02.10.2019 | Event News
19.09.2019 | Event News
18.10.2019 | Power and Electrical Engineering
18.10.2019 | Medical Engineering
18.10.2019 | Physics and Astronomy