Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New theory in neuroscience by UNIST Research Team: common mechanisms in Fragile X and Down syndrome

04.10.2013
A new common mechanism in Fragile X and Down syndrome has been identified by scientists at Ulsan National Institute of Science and Technology (UNIST), Korea and published in the world leading science journal, Trends in Neurosciences (Cell Press).

A new common mechanism in Fragile X and Down syndrome has been identified by scientists at Ulsan National Institute of Science and Technology (UNIST), Korea and published in the world leading science journal, Trends in Neurosciences (Cell Press). (Title : Meeting at the crossroads: Common mechanisms in Fragile X and Down syndrome, http://dx.doi.org/10.1016/j.tins.2013.08.007)

Emerging evidence shows that the regulation of local protein synthesis in dendritic spines plays a crucial role in controlling synaptic morphogenesis and synaptic efficacy. However, scientist do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory.

The research team led by Prof. Kyung-Tai Min from UNIST presented evidence that pathways controlled by DSCR1 and FMRP, genes implicated in two of the most common genetic causes of intellectual disabilities – DS and FXS converge to regulate spine morphogenesis, local protein synthesis, and neurotransmission.

Min’s research team highlighted the *previous research work published in The EMBO Journal by Prof. Min, showing that some of the proteins altered in Fragile X and Down syndrome are common molecular triggers of intellectual disability in both disorders, DS and FXS.

*Title: DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis (The EMBO Journal (2012) 31, 3655 – 3666 )

They reviewed other genes encoded by chromosome 21 that may regulate dendritic spine morphogenesis and contribute to intellectual disabilities by acting through pathways involving FMRP and DSCR1.

The research work provided an important stepping stone in understanding the multiple roles of DSCR1 in neurons and in identifying a molecule that is closely linked to intellectual disability for both syndromes.

“We will continuously investigate whether reducing FMRP in DS mouse model or elevating DSCR1 in FMRP knockout mice could restore synaptic plasticity, dendritic spine morphogenesis, and local protein synthesis will further advance our understanding of both diseases,” said Prof. Min, presenting future research plan.

“Further elucidation of the large functional protein-inter-action network that regulates local protein synthesis, spine morphogenesis, and synaptic transmission may also shed light on overlapping molecular pathways that cause intellectual disabilities in different disorders,” added Prof. Min.

This research work was supported by grants from Ulsan National Institute of Science and Technology, the Korea Ministry of Education, Science and Technology and Foundation Jerome Lejeune.

Ulsan National Institute of Science and Technology (UNIST) http://www.unist.ac.kr
Homepage of Prof. Kyung-Tai Min http://minlab.unist.ac.kr/
The original press release can be found at
https://www.unist.ac.kr/board/view.sko?boardId=Notice&boardSid=5037&menuCd=AB07002001000&contentsSid=8297&orderBy=register_dt&startPage=1&searchType=&keyword=&searchStartDt=&searchEndDt=&dataSid=2377338

Associated links
http://www.unist.ac.kr
http://minlab.unist.ac.kr
Journal information
Trends in Neurosciences (Cell Press)
Funding information
UNIST, the Korea Ministry of Education, Science and Technology and Foundation Jerome Lejeune

Eunhee Song | Research asia research news
Further information:
http://www.unist.ac.kr
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

nachricht Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Research finds new molecular structures in boron-based nanoclusters

13.07.2018 | Materials Sciences

Algae Have Land Genes

13.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>